Rapid palladium-catalyzed cross-coupling in the synthesis of aryl thioethers under microwave conditions
Rapid palladium-catalyzed cross-coupling in the synthesis of aryl thioethers under microwave conditions
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DOI：
10.1016/j.tetlet.2006.04.049
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发表时间：
2006-06-26
影响因子：
1.8
通讯作者：
Pike, Victor W.
中科院分区：
文献类型：
--
作者：
Cai, Lisheng;Cuevas, Jessica;Pike, Victor W.
研究了微波条件下pd催化芳香族碘化物或溴化物与硫酸锡的偶联反应，合成了芳香族硫醚，同时没有生成还原物。配体筛选显示DiPPF和BINAP-Tol是这种转化最常用的配体。多种碘化物或溴化物偶联得到硫醚快速（10分钟）在60-95%分离收率。(c) 2006 Elsevier Ltd.版权所有。
A Pd-catalyzed coupling of aromatic iodides or bromides and tin-thiolates under microwave conditions was developed to synthesize aromatic thioethers without concomitant formation of the reduced products. Ligand screening revealed DiPPF and BINAP-Tol as the most generally useful ligands for this transformation. A variety of iodides or bromides were coupled to give the thioethers rapidly (10 min) in 60-95% isolated yield. (c) 2006 Elsevier Ltd. All rights reserved.