Response of naive and memory CD8+ T cells to antigen stimulation in vivo
Response of naive and memory CD8+ T cells to antigen stimulation in vivo
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DOI：
10.1038/76907
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发表时间：
2000-07-01
影响因子：
30.5
通讯作者：
Rocha, B
中科院分区：
文献类型：
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作者：
Veiga-Fernandes, H;Walter, U;Rocha, B
我们通过比较相同数量的T细胞受体（TCR）转基因（Tg）初始和记忆T细胞的体内免疫应答，研究了记忆T细胞特性对二次免疫应答效率的影响。与初始Tg细胞相比，记忆细胞在较短的滞后时间后分裂;具有增加的分裂速率;较低的损失率;并且显示出向效应器功能的快速和有效的分化。我们发现初始幼稚T细胞引发导致细胞表达相互排斥的效应子功能，而记忆T细胞在重新激活后是多功能的，每个细胞同时表达两到三种不同的效应子功能。记忆T细胞的这些特殊性质确保了对再感染的立即控制。
We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the in vivo immune response of the same numbers of T cell receptor (TCR) transgenic (Tg) naive and memory T cells. Compared to naive Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and showed move rapid and efficient differentiation to effector functions. We found that initial naive T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T cells ensure the immediate control of reinfection.