The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes
The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes
复制标题
DOI：
10.1111/j.1365-2788.2010.01337.x
复制
发表时间：
2011-02-01
影响因子：
3.6
通讯作者：
Burbidge, C.
中科院分区：
文献类型：
--
作者：
Arron, K.;Oliver, C.;Burbidge, C.
背景自我伤害和攻击行为被报道为一些行为表型的组成部分，但很少有研究比较综合征组。在这项研究中，我们研究了这些行为的患病率和相关的人的特点，在七个遗传syndromes.MethodsQuestionnaire数据的自我伤害和攻击，情绪，多动，自闭症谱系障碍和重复行为收集了天使人（AS，n = 104），科尔内利亚de Lange（CdLS，101），Cri du Chat（CdCS，58），脆性X（FXS，191），Lowe（LS，56），Prader-Willi结果CdCS、CdLS、FXS、PWS、LS和SMS的自伤发生率明显高于对照组（P <0.05）。攻击的患病率显着提高AS和SMS。在CdLS、FXS、PWS和LS中，自伤与重复和冲动行为相关。冲动和过度活跃显着较高的侵略在所有syndrome groups.ConclusionsThese数据量化的风险自伤和侵略的综合征研究与早期干预的影响。这些行为和个人特征之间的关联，无论是在综合征内和综合征之间，都需要进一步的研究。
BackgroundSelf-injurious and aggressive behaviours are reported as components of some behavioural phenotypes but there are few studies comparing across syndrome groups. In this study we examined the prevalence of these behaviours and the associated person characteristics in seven genetic syndromes.MethodsQuestionnaire data on self-injury and aggression, mood, hyperactivity, autism spectrum disorder and repetitive behaviour were collected on Angelman (AS, n = 104), Cornelia de Lange (CdLS, 101), Cri du Chat (CdCS, 58), Fragile X (FXS, 191), Lowe (LS, 56), Prader-Willi (PWS, 189) and Smith-Magenis (SMS, 42) syndromes.ResultsA significantly higher prevalence of self-injury was evident in CdCS, CdLS, FXS, PWS, LS and SMS. The prevalence of aggression was significantly heightened in AS and SMS. Self-injury was associated with repetitive and impulsive behaviour in CdLS, FXS, PWS and LS. Impulsivity and overactivity were significantly higher in those showing aggression across all syndrome groups.ConclusionsThese data quantify the risk for self-injury and aggression in the syndromes studied with implications for early intervention. The associations between these behaviours and person characteristics both within and between syndromes warrant further research.