HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.
HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.
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DOI：
10.18632/oncotarget.15077
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发表时间：
2017-03-14
期刊：
影响因子：
--
通讯作者：
Mi QS
中科院分区：
文献类型：
--
作者：
Liu Q;Zhang X;Yin C;Chen X;Zhang Z;Brown S;Xie H;Zhou L;Mi QS
组蛋白去乙酰化是由组蛋白去乙酰化酶（HDAC）和乙酰转移酶介导的，是翻译后修饰的主要形式之一。先前的研究表明，HDAC在各种免疫细胞的发育中起着重要的调节作用。然而，个体HDAC的具体功能在很大程度上仍未被探索。HDAC4是第二类HDACs的成员之一，在神经系统中被深入研究，而HDAC4在T细胞中的表达谱和功能几乎不为人知。这是我们第一次报道HDAC4在多种T细胞谱系中表达。使用T细胞特异性HDAC4缺陷小鼠，我们发现缺乏HDAC4不会改变胸腺和次级淋巴器官中常规T细胞，不变NKT（iNKT）细胞或调节性T细胞的频率。此外，来自野生型和HDAC4缺陷型小鼠的常规T细胞和iNKT细胞在细胞因子产生方面没有显示出显著差异。总之，我们的研究结果表明，在稳定阶段，HDAC 4不是多种T细胞谱系（包括常规T细胞和iNKT细胞）的发育和功能所必需的。
Histone deacetylation, reciprocally mediated by histone deacetylases (HDAC) and acetyltransferases, represents one major form of post-translational modification. Previous research indicates that HDACs play an essential regulatory role in the development of various immune cells. However, the specific function of individual HDACs remains largely unexplored. HDAC4, a member of class II HDACs, profoundly investigated in the nervous system, while the expression profile and function of HDAC4 in T cells are barely known. For the first time, we report here that HDAC4 is expressed in the multiple T cell lineages. Using T-cell-specific HDAC4-deficient mice, we discovered that lack of HDAC4 did not alter the frequencies of conventional T cells, invariant NKT (iNKT) cells or regulatory T cells within both the thymus and secondary lymphoid organs. Moreover, conventional T cells and iNKT cells from wild-type and HDAC4-deficient mice displayed no significant difference in cytokine production. In conclusion, our results imply that under steady stage, HDAC4 is not required for the development and function of multiple T cell lineages, including conventional T cells and iNKT cells.