A mutation in the decoding center of Thermus thermophilus 16S rRNA suggests a novel mechanism of streptomycin resistance
A mutation in the decoding center of Thermus thermophilus 16S rRNA suggests a novel mechanism of streptomycin resistance
复制标题
DOI：
10.1128/jb.187.6.2200-2202.2005
复制
发表时间：
2005-03-01
影响因子：
3.2
通讯作者：
Dahlberg, AE
中科院分区：
文献类型：
--
作者：
Gregory, ST;Carr, JF;Dahlberg, AE
在极端嗜热菌Thermus thermophilus中发现了16S rRNA解码中心的自发卡那霉素抗性和卷曲霉素抗性突变A1408G。出乎意料的是，这种突变也赋予了链霉素抗性。我们提出了一种新的链霉素抗性机制，A1408G 通过该机制影响 tRNA 选择过程中 16S rRNA 的构象变化。
A spontaneous kanamycin resistance and capreomycin resistance mutation, A1408G, in the decoding center of 16S rRNA, was identified in the extreme thermophile Thermus thermophilus. Unexpectedly, this mutation also confers resistance to streptomycin. We propose a novel mechanism of streptomycin resistance by which A1408G influences conformational changes in 16S rRNA during tRNA selection.