A novel application of metabolomics in vertebrate development
A novel application of metabolomics in vertebrate development
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DOI：
10.1016/j.bbrc.2009.06.041
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发表时间：
2009-08-14
影响因子：
3.1
通讯作者：
Fukusaki, Eiichiro
中科院分区：
文献类型：
--
作者：
Hayashi, Shunsuke;Akiyama, Shinichi;Fukusaki, Eiichiro
许多研究已经证明了与胚胎发生相关的单个基因的功能，并确定了几种生物的基因组序列。尽管有大量的遗传信息，但胚胎发生过程中发生的动态变化尚未完全了解。为了了解胚胎发生的动态过程，我们采用了代谢组学的方法。研究结果表明，代谢组与发育阶段之间存在密切的相关性。我们的方法能够使用代谢组作为“指纹”来鉴定胚胎阶段。“通过这种方式，我们可以根据代谢组学指纹成功地预测胚胎发育。这是第一个报告描述了一个模型，预测脊椎动物的发展，利用代谢组学。(C)2009 Elsevier Inc. All rights reserved.
Many Studies have demonstrated the functions of individual genes associated with embryogenesis and have determined the genome sequences of several organisms. Despite the availability of enormous amount of genetic information, dynamic changes that occur during embryogenesis have not yet been completely understood. In order to understand the dynamic processes involved in embryogenesis, we employed the metabolomic approach. The results of our study indicated that there is a close correlation between metabolomes and developmental stages. Our method enables the identification of embryonic stages using metabolomes as "fingerprints." In this manner, we could successfully predict embryonic development on the basis of metabolomic fingerprints. This is the first report describing a model for predicting vertebrate development by using metabolomics. (C) 2009 Elsevier Inc. All rights reserved.