The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography.
The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence tomography.
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DOI：
10.1001/archopht.118.1.22
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发表时间：
2000
影响因子：
--
通讯作者：
C. Bowd;R. Weinreb;Julia M. Williams;L. Zangwill
中科院分区：
文献类型：
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作者：
C. Bowd;R. Weinreb;Julia M. Williams;L. Zangwill
目的利用光学相干断层扫描（OCT 2000，软件版本A4X1； Humphrey Instruments, San Leandro, california）定量评价和比较高眼压眼与正常眼和青光眼视网膜神经纤维层（RNFL）的厚度。方法将高眼压（28只）眼与年龄匹配的正常（30只）眼和青光眼（29只）眼的RNFL平均厚度进行比较。受试者的眼睛根据眼压、立体椎间盘照片和标准的自动视野检查分为诊断组。每只眼睛视盘周围直径3.4 mm处进行三次圆形扫描。在每只眼睛中，在颞、上、鼻和下象限获得平均RNFL厚度测量值。还获得了整个360度的平均RNFL厚度的单一指标。结果高眼压眼的RNFL平均值（95%可信区间）明显小于正常眼，分别为72.8微米（66.4-78.1微米）和85.8微米（80.2-91.7微米）。更具体地说，下象限高眼压眼的RNFL明显比正常眼薄，分别为84.8微米（75.6-94.0微米）和107.6微米（99.3-115.9微米）；在鼻象限，44.1微米（37.5-51.7微米）vs 61.8微米（53.0-65.6微米）。青光眼的视网膜神经纤维层在360度和所有象限范围内均明显薄于眼高血压和正常眼。结论：在年龄匹配的高眼压、正常眼和青光眼之间，RNFL厚度存在定量差异。
OBJECTIVE To quantitatively assess and compare the thickness of the retinal nerve fiber layer (RNFL) in ocular hypertensive eyes with normal and glaucomatous eyes using the Optical Coherence Tomograph (OCT 2000, software version A4X1; Humphrey Instruments, San Leandro, Calif). METHODS The mean RNFL thickness of ocular hypertensive (n = 28) eyes was compared with age-matched normal (n = 30) and glaucomatous (n = 29) eyes. Subject eyes were classified into diagnostic groups based on intraocular pressure, stereoscopic disc photographs, and standard automated perimetry. Three circular scans were obtained for each eye at a diameter of 3.4 mm around the optic disc. In each eye, average RNFL thickness measurements were obtained in temporal, superior, nasal, and inferior quadrants. A single index of average RNFL thickness throughout 360 degrees also was obtained. RESULTS Mean (95% confidence interval) RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes, 72.8 microm (66.4-78.1 microm) and 85.8 microm (80.2-91.7 microm), respectively. More specifically, RNFL was significantly thinner in ocular hypertensive eyes than in normal eyes in the inferior quadrant, 84.8 microm (75.6-94.0 microm) vs 107.6 microm (99.3-115.9 microm); and in the nasal quadrant, 44.1 microm (37.5-51.7 microm) vs 61.8 microm (53.0-65.6 microm). Retinal nerve fiber layer was significantly thinner in glaucomatous eyes than in ocular hypertensive and normal eyes throughout 360 degrees and in all quadrants. CONCLUSION These findings suggest that quantitative differences in RNFL thickness exist between age-matched ocular hypertensive, normal, and glaucomatous eyes.