The fission yeast spindle orientation checkpoint: a model that generates tension?
The fission yeast spindle orientation checkpoint: a model that generates tension?
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DOI：
10.1002/yea.1410
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发表时间：
2006-10-15
期刊：
影响因子：
2.6
通讯作者：
Tournier, Sylvie
中科院分区：
文献类型：
--
作者：
Gachet, Yannick;Reyes, Celine;Tournier, Sylvie
在所有真核生物中，有丝分裂纺锤体与细胞极性轴的对齐对于染色体的准确分离以及细胞命运的建立以及发育过程中的形态发生至关重要。对无脊椎动物、高等真核生物和酵母的研究表明，星状微管与细胞皮层相互作用，定位纺锤体。这些微管被认为对主轴杆施加推力或拉力，以影响主轴的旋转或运动。在分裂酵母模型中，细胞分裂是对称的，纺锤体旋转依赖于星状微管与皮质肌动蛋白细胞骨架的相互作用。在这些细胞中，当纺锤体不能与细胞极性轴对齐时，一个依赖于bub1的有丝分裂检查点，纺锤体取向检查点（SOC）被激活。本文综述了分裂酵母有丝分裂过程中纺锤体定向的机制，并讨论了定向错误对中期进程的影响。版权所有(c) 2006约翰威利父子有限公司
In all eukaryotes, the alignment of the mitotic spindle with the axis of cell polarity is essential for accurate chromosome segregation as well as for the establishment of cell fate, and thus morphogenesis, during development. Studies in invertebrates, higher eukaryotes and yeast suggest that astral microtubules interact with the cell cortex to position the spindle. These microtubules are thought to impose pushing or pulling forces on the spindle poles to affect the rotation or movement of the spindle. In the fission yeast model, where cell division is symmetrical, spindle rotation is dependent on the interaction of astral microtubules with the cortical actin cytoskeleton. In these cells, a bub1-dependent mitotic checkpoint, the spindle orientation checkpoint (SOC), is activated when the spindles fail to align with the cell polarity axis. In this paper we review the mechanism that orientates the spindle during mitosis in fission yeast, and discuss the consequences of misorientation on metaphase progression. Copyright (c) 2006 John Wiley & Sons, Ltd.