Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker
Functionalizable and nonfouling zwitterionic carboxybetaine hydrogels with a carboxybetaine dimethacrylate crosslinker
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DOI：
10.1016/j.biomaterials.2010.09.067
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发表时间：
2011-02-01
期刊：
影响因子：
14
通讯作者：
Jiang, Shaoyi
中科院分区：
文献类型：
--
作者：
Carr, Louisa R.;Xue, Hong;Jiang, Shaoyi
我们已经引入了一种基于二甲基丙烯酸酯羧基甜菜碱的交联剂，其与两性离子水凝胶系统具有优异的相容性。用新型CBMA交联剂（CBMAX）制备的聚（羧基甜菜碱甲基丙烯酸酯）（pCBMA）水凝胶与用市售N，N '-亚甲基双（丙烯酰胺）（MBAA）交联剂制备的水凝胶相比，溶解性、均匀性和机械性能（压缩模量高达8 MPa）得到显著改善。CBMAX交联剂的两性离子性质提供了CBMA水凝胶中有序水合的连续性，并保留了其不结垢特性。CBMAX交联的CBMA水凝胶具有比MBAA交联的CBMA水凝胶更低的细胞结垢，并且实际上相对于pHEMA水凝胶将细胞粘附降低约90%。此外，与pHEMA不同，CBMA水凝胶易于官能化。通过cRGD官能化控制细胞在无污染CBMA水凝胶上的粘附。(c)2010爱思唯尔有限公司版权所有。
We have introduced a dimethacrylate carboxybetaine-based crosslinker that has excellent compatibility with zwitterionic hydrogel systems. Poly(carboxybetaine methacrylate) (pCBMA) hydrogels prepared with the new CBMA crosslinker (CBMAX) result in considerably improved solubility, homogeneity, and mechanical properties (up to 8 MPa compressive modulus) over those prepared with the commercially available N,N'-methylenebis(acrylamide) (MBAA) crosslinker. The zwitterionic nature of the CBMAX crosslinker provides continuity of ordered hydration in the CBMA hydrogel and retains its nonfouling properties. CBMAX-crosslinked CBMA hydrogels had lower cell fouling than MBAA-crosslinked CBMA hydrogels and in fact reduced cell adhesion by about 90% relative to pHEMA hydrogels. Furthermore, unlike pHEMA, CBMA hydrogels are readily functionalizable. Cell adhesion on nonfouling CBMA hydrogels was controlled by cRGD functionalization. (c) 2010 Elsevier Ltd. All rights reserved.