Decrease in polyamines with aging and their ingestion from food and drink
Decrease in polyamines with aging and their ingestion from food and drink
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DOI：
10.1093/jb/mvj003
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发表时间：
2006-01-01
影响因子：
2.7
通讯作者：
Igarashi, K
中科院分区：
文献类型：
--
作者：
Nishimura, K;Shiina, R;Igarashi, K
在3周、10周和26周大的雌性小鼠中测量了衰老过程中多胺水平的变化。在此期间，胰腺、大脑和子宫的多胺水平保持不变。在此期间，小肠亚精胺水平略有下降，胸腺、脾脏、卵巢、肝脏、胃、肺、肾脏、心脏和肌肉的亚精胺水平显著下降。在皮肤中，亚精胺水平在10周龄小鼠中最高，在26周龄小鼠中显著降低。结果表明，多胺水平的维持可能在3- 26周龄小鼠的胰腺、大脑和子宫功能中发挥重要作用。接下来，我们寻找富含多胺的食物材料作为多胺的膳食来源。富含多胺的食物包括：小麦胚芽、米糠、黑米、菲律宾芒果、青椒、日本南瓜、坚果、发酵酸菜、塘臭、包壳内脏、海螺内脏、盐渍三文鱼籽、盐渍鳕鱼籽、牛肠（水煮）和鳗鱼、牛肉、猪肉和鸡肉的肝脏；如前所述，大豆、发酵大豆（纳豆）、蘑菇、橙茶和绿茶。当需要从食物中摄取多胺时，这些结果提供了有用的信息。
Changes in polyamine levels during aging were measured in 3-, 10- and 26-week-old female mice. The level of polyamines in pancreas, brain, and uterus was maintained during these periods.. The level of spermidine slightly decreased in intestine, and decreased significantly in thymus, spleen, ovary, liver, stomach, lung, kidney, heart and muscle during these periods. In skin, the level of spermidine was maximal in 10-week-old mice and markedly reduced in 26-week-old mice. The results suggest that maintenance of polyamine levels may play important roles in the function of the pancreas, brain and uterus in 3- to 26-week-old mice. We next looked for polyamine-rich food materials as a dietary source of polyamines. Foods found to be rich in polyamines included wheat germ, rice bran, black rice, Philippine mango, green pepper, Japanese pumpkin, nuts, fermented pickles, pond smelt, turban shell viscera, whelk viscera, salted salmon roe, salted cod roe, beef intestine (boiled) and liver of eel, beef, pork and chicken; and, as previously reported, soybean, fermented soybean (natto), mushrooms, orange and green tea leaf. These results offer useful information when it becomes necessary to ingest polyamines from food.