Rho kinase signaling and cardiac physiology.
Rho kinase signaling and cardiac physiology.
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DOI：
10.1016/j.cophys.2017.07.005
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发表时间：
2018-03
影响因子：
2.5
通讯作者：
Chang J
中科院分区：
文献类型：
--
作者：
Dai Y;Luo W;Chang J
Rho激酶（ROCKs）是第一个发现的RhoA效应子，其对肌动蛋白组织的作用现在广为人知。最近的研究表明，ROCK在心脏生理学中发挥重要作用。ROCKs的异常激活参与多种心血管病理过程，包括心肌肥厚、凋亡、纤维化、系统性高血压和肺动脉高压。ROCK抑制剂法舒地尔和他汀类药物在许多动物研究、临床试验和应用中显示出有益的心血管作用。本文主要讨论了Rho激酶信号在心脏中的生理作用，并简要总结了ROCKs在心脏相关血管功能障碍中的作用。我们还将讨论ROCK抑制剂的临床应用。
Rho kinases (ROCKs) are the first discovered RhoA effectors that are now widely known for their effects on actin organization. Recent studies have shown that ROCKs play important roles in cardiac physiology. Abnormal activation of ROCKs participate in multiple cardiovascular pathological processes, including cardiac hypertrophy, apoptosis, fibrosis, systemic hypertension, and pulmonary hypertension. ROCK inhibitors, fasudil and statins, have shown beneficial cardiovascular effects in many animal studies, clinical trials, and applications. Here, we mainly discuss the current understanding of the physiological roles of Rho kinase signaling in the heart, and briefly summarize the roles of ROCKs in cardiac-related vascular dysfunctions. We will also discuss the clinical application of ROCK inhibitors.