Progress toward UNAIDS 90-90-90 targets: A respondent-driven survey among female sex workers in Kampala, Uganda
Progress toward UNAIDS 90-90-90 targets: A respondent-driven survey among female sex workers in Kampala, Uganda
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DOI：
10.1371/journal.pone.0201352
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发表时间：
2018-09-19
期刊：
影响因子：
3.7
通讯作者：
Hladik, Wolfgang
中科院分区：
文献类型：
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作者：
Doshi, Reena H.;Sande, Enos;Hladik, Wolfgang
背景我们调查了乌干达坎帕拉女性性工作者实现联合国艾滋病规划署90-90-90目标的进展情况，她们承担着不成比例的艾滋病毒负担。方法在2012年4月至12月期间，采用受访者驱动的抽样方法招募了1,487名女性性工作者，她们的定义是15-49岁的女性，居住在大坎帕拉，最近6个月以性交易换取金钱。采集静脉血进行艾滋病毒和病毒载量测试[病毒载量抑制(VLS)定义为1,000拷贝/毫升]。我们通过音频计算机辅助自访收集数据，并计算加权的人口水平估计。结果中位年龄为27岁(四分位数范围：23至32岁)。HIV血清阳性率为31.4%(95%可信区间：29.0，33.7%)。在所有检测出HIV阳性的女性性工作者中(人群水平目标)，45.5%(95%CI：40.1，51.0)知道她们的血清状态(人群水平目标：90%)，37.8%(95%CI：32.2，42.8)自我报告服用ART(人口水平目标：81%)，35.2%(95%CI：20.7，30.4)病毒抑制(人口水平目标：73%)。然而，血清学知识和VLS远远低于联合国艾滋病规划署的目标。坎帕拉女性性工作者需要加强和有针对性地预防和控制艾滋病毒。
BackgroundWe investigated progress towards UNAIDS 90-90-90 targets among female sex workers in Kampala, Uganda, who bear a disproportionate burden of HIV.MethodsBetween April and December 2012, 1,487 female sex workers, defined as women, 15 - 49 years, residing in greater Kampala, and selling sex for money in the last 6 months, were recruited using respondent-driven sampling. Venous blood was collected for HIV and viral load testing [viral load suppression (VLS) defined as < 1,000 copies/mL]. We collected data using audio computer-assisted self-interviews and calculated weighted population-level estimates.ResultsThe median age was 27 years (interquartile range: 23 to 32). HIV seroprevalence was 31.4% (95% confidence interval [CI]: 29.0, 33.7%). Among all female sex workers who tested HIV-positive in the survey (population-level targets), 45.5% (95% CI: 40.1, 51.0) had knowledge of their serostatus (population-level target: 90%), 37.8% (95% CI: 32.2, 42.8) self-reported to be on ART (population-level target: 81%), and 35.2% (95% CI: 20.7, 30.4) were virally suppressed (population-level target: 73%).ConclusionsHIV prevalence among Kampala female sex workers is high, whereas serostatus knowledge and VLS are far below UNAIDS targets. Kampala female sex workers are in need of intensified and targeted HIV prevention and control efforts.