The MreB and Min cytoskeletal‐like systems play independent roles in prokaryotic polar differentiation
The MreB and Min cytoskeletal‐like systems play independent roles in prokaryotic polar differentiation
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DOI：
10.1111/j.1365-2958.2005.04841.x
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发表时间：
2005-11
影响因子：
3.6
通讯作者：
Y. Shih;I. Kawagishi;L. Rothfield
中科院分区：
文献类型：
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作者：
Y. Shih;I. Kawagishi;L. Rothfield
细胞极轴的建立和细胞极点的分化是许多生物细胞发育的基本方面。我们比较了两个细菌细胞骨架系统，MreB和MinCDE系统，在大肠杆菌中对这些过程的影响。我们报道Min蛋白能够建立一个振动轴，这是在球形细胞中建立极性的第一步，在一个独立于MreB细胞骨架的过程中。相反，在一个独立于Min系统的过程中，MreB系统对于建立细胞的杆状形状和其他极性成分的极性靶向是必需的，例如志贺氏菌毒力因子ICSA和天冬氨酸化学感受器Tar。因此，这两个细菌类细胞骨架系统在细胞极化的不同方面独立发挥作用。
Establishment of an axis of cell polarity and differentiation of the cell poles are fundamental aspects of cellular development in many organisms. We compared the effects of two bacterial cytoskeletal‐like systems, the MreB and MinCDE systems, on these processes in Escherichia coli. We report that the Min proteins are capable of establishing an axis of oscillation that is the initial step in establishment of polarity in spherical cells, in a process that is independent of the MreB cytoskeleton. In contrast, the MreB system is required for establishment of the rod shape of the cell and for polar targeting of other polar constituents, such as the Shigella virulence factor IcsA and the aspartate chemoreceptor Tar, in a process that is independent of the Min system. Thus, the two bacterial cytoskeletal‐like systems act independently on different aspects of cell polarization.