Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.
Correlation of single-breath count test and neck flexor muscle strength with spirometry in myasthenia gravis.
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DOI：
10.1002/mus.24929
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发表时间：
2016-01
期刊：
影响因子：
3.4
通讯作者：
Kissel JT
中科院分区：
文献类型：
--
作者：
Elsheikh B;Arnold WD;Gharibshahi S;Reynolds J;Freimer M;Kissel JT
Although formal spirometry is the gold standard for monitoring respiratory function in patients with myasthenia gravis (MG), such testing is often delayed or unavailable. There is a need for a simple bedside test that can accurately measure respiratory function. We conducted a prospective, cross-sectional, single-blind study in adults with acetylcholine receptor antibody positive MG. Participants performed the single breath count test (SBCT) and underwent manual muscle strength testing, while a respiratory therapist performed spirometry blinded to SBCT and strength results. Thirty-one patients, aged 57 ±19 years participated. SBCT showed significant correlations with forced vital capacity (FVC), negative inspiratory force (NIF), and neck flexor strength (P<0.01). FVC showed significant correlation with neck flexor strength (P=0.02) but no correlation with shoulder abductor strength. These data suggest that the SBCT and neck flexor strength testing are valuable tools for bedside assessment of respiratory function in MG patients.
