Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1
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DOI：
10.1016/j.ccr.2012.10.012
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发表时间：
2012-12-11
期刊：
影响因子：
50.3
通讯作者：
Angela Nieto, M.
中科院分区：
文献类型：
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作者：
Ocana, Oscar H.;Corcoles, Rebeca;Angela Nieto, M.
上皮-间质转化（EMT）是胚胎组织形成所必需的，细胞起源于远离最终目的地的地方。癌细胞劫持了这个程序来传播肿瘤。EMT在癌症中的相关性仍然存在争议，因为尚不清楚这些迁移细胞如何定植到远处组织形成大转移。我们发现同源盒因子Prrx1是一种EMT诱导剂，具有迁移和侵袭特性。Prrx1的缺失是癌细胞在体内转移所必需的，癌细胞在获得干细胞特性的同时恢复到上皮表型。因此，与经典的EMT转录因子不同，Prrx1将EMT和严重度分开，是与患者生存和缺乏转移相关的生物标志物。
The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of tissues for which cells originate far from their final destination. Carcinoma cells hijack this program for tumor dissemination. The relevance of the EMT in cancer is still debated because it is unclear how these migratory cells colonize distant tissues to form macrometastases. We show that the homeobox factor Prrx1 is an EMT inducer conferring migratory and invasive properties. The loss of Prrx1 is required for cancer cells to metastasize in vivo, which revert to the epithelial phenotype concomitant with the acquisition of stem cell properties. Thus, unlike the classical EMT transcription factors, Prrx1 uncouples EMT and sternness, and is a biomarker associated with patient survival and lack of metastasis.