The burden of anaemia in type 2 diabetes and the role of nephropathy: a cross-sectional audit
The burden of anaemia in type 2 diabetes and the role of nephropathy: a cross-sectional audit
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DOI：
10.1093/ndt/gfh248
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发表时间：
2004-07-01
影响因子：
6.1
通讯作者：
Jerums, G
中科院分区：
文献类型：
--
作者：
Thomas, MC;MacIsaac, RJ;Jerums, G
背景资料。贫血是糖尿病患者的常见症状，对于高龄患者和合并血管疾病的患者来说，贫血是额外的负担。本研究从三个大型临床中心调查长期门诊2型糖尿病患者的贫血患病率及其预测因素。在墨尔本奥斯汀医学中心(n=670)、澳大利亚悉尼皇家阿尔弗雷德王子医院(n=915)和皇家北岸医院(n=540)对所有长期随访的2型糖尿病患者进行的横断面调查中，除了常规检测外，还获得了完整的血细胞计数。用多因素Logistic回归分析确定贫血的患病率及其相关因素(男性为130g/L，女性为120g/L)。粗略地说，每个中心每五个患者中就有一个患有贫血。最危险的患者可以很容易地通过肾脏疾病的存在来识别，表现为75%的贫血患者肾功能受损和/或蛋白尿。糖尿病和轻度肾损害患者发生贫血的可能性是肾功能正常者的两倍(Ccr：90ml/min/1.73m(2))。伴有中度肾损害(CCR)的糖尿病患者
Background. Anaemia is a common finding in patients with diabetes and constitutes an additional burden in patients with advancing age and comorbid vascular disease. This study examines the prevalence and predictors of anaemia in long-term outpatients with type 2 diabetes from three large clinical centres.Methods. A full blood count was obtained in addition to routine testing in a cross-sectional survey of all patients with type 2 diabetes in long-term follow-up at the Austin Medical Centre, Melbourne (n = 670) and the Royal Prince Alfred Hospital (n = 915) and the Royal North Shore Hospital (n = 540), Sydney, Australia. The prevalence and correlates of anaemia (haemoglobin < 130 g/l in men and < 120 g/l in women) were identified using multivariate logistic regression.Results. Roughly, one in five patients in each centre had anaemia. Patients at greatest risk could be readily identified by the presence of renal disease, manifested as impaired renal function and/or albuminuria in >75% of patients with anaemia. Patients with diabetes and mild renal impairment [creatinine clearance (CCr) 60-90 ml/min/1.73 m(2)] were twice as likely to have anaemia as those with normal renal function (CCr >90 ml/min/1.73 m(2)). Diabetics with moderate renal impairment (CCr