LIVER AND SKELETAL-MUSCLE MITOCHONDRIAL-FUNCTION FOLLOWING BURN INJURY
LIVER AND SKELETAL-MUSCLE MITOCHONDRIAL-FUNCTION FOLLOWING BURN INJURY
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DOI：
10.1097/00005373-197704000-00004
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发表时间：
1977-01-01
影响因子：
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通讯作者：
RULFS, J
中科院分区：
文献类型：
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作者：
APRILLE, JR;HOM, JA;RULFS, J
研究了烧伤后线粒体功能改变的可能性。从烧伤大鼠（20%tbs）的肝脏或骨骼肌中分离的线粒体在烧伤后3天与假手术组和正常对照组进行比较。所有组的线粒体产量相同。ADP：O比值在预期的理论范围内，并且在烧伤、假手术和正常动物之间没有差异。肝线粒体呼吸控制率（RCR）降低。烧伤动物平均为正常值的71.7%，而假手术组为95.8%。肝线粒体呼吸控制的丧失意味着底物化学能的低效利用，并可能导致烧伤后高代谢。与肝脏相比，肌肉线粒体的不同反应表明改变可能是器官特异性的。
The possibility of altered mitochondrial function consequent to burn injury was investigated. Mitochondria isolated from liver or skeletal muscle of burn-injured rats (20% tbs) were compared at 3 days postburn to shams and normal controls. Mitochondrial yields were the same for all groups. ADP: O ratios were in the theoretical ranges expected and did not differ among burn, sham, and normal animals. Respiratory control ratios (RCR's) were decreased in liver mitochondria. averaging 71.7% of normal for burned animals compared to 95.8% for the sham group. The loss of respiratory control in liver mitochondria implies inefficient use of substrate chemical energy and could contribute to postburn hypermetabolism. The different response of muscle mitochondria as compared to liver suggests that alterations may be organ specific.