CEREBRAL BLOOD-FLOW AND EDEMA FOLLOWING CAROTID OCCLUSION IN THE GERBIL
CEREBRAL BLOOD-FLOW AND EDEMA FOLLOWING CAROTID OCCLUSION IN THE GERBIL
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DOI：
10.1161/01.str.11.5.494
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发表时间：
1980-01-01
期刊：
影响因子：
8.3
通讯作者：
SYMON, L
中科院分区：
文献类型：
--
作者：
CROCKARD, A;IANNOTTI, F;SYMON, L
本文介绍了一种测量沙土鼠脑局部血流量(CBF)和脑比重(SG)的方法，并测试了二氧化碳的反应性和自动调节能力。平均脑血流量为29.5±-。4.5ml/100g/min，脑SG 1.0500.+-。0.0004。单侧颈动脉闭塞导致血流减少至12.8+-。同侧大脑半球5.8ml/100g/min，对侧大脑半球变化不大，脑组织SG降低。脑缺血后1小时，脑血流量为20ml/100g/min时出现脑水肿，至7.+-时达最大水平。2ml/100g/min。水肿量似乎主要与闭塞后的残余血流有关。双侧闭塞时，脑血流量接近于零，脑血流量无明显变化；无血流状态下，脑血流量无明显变化。
A technique for measuring focal cerebral blood flow (CBF) and brain specific gravity (SG) in gerbils is described; CO2 reactivity and autoregulation were tested. The mean CBF was 29.5 .+-. 4.5 ml/100 g per min and brain SG 1.0500 .+-. 0.0004. Unilateral carotid occlusion resulted in a reduction of flow to 12.8 .+-. 5.8 ml/100 g per min in the ipsilateral hemisphere with little change in the contralateral hemisphere; there was a decrease in brain SG. One hour after occlusion, brain edema as judged by decreased SG developed at CBF < 20 ml/100 g per min and reached maximal levels at 7 .+-. 2 ml/100 g per min. The amount of edema appeared to be related chiefly to the residual post-occlusion flow. With bilateral occlusion CBF was close to zero and there was no change in SG; in the no flow situation there is no edema.