Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils
Pseudomonas aeruginosa OxyR is required for full virulence in rodent and insect models of infection and for resistance to human neutrophils
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DOI：
10.1128/iai.73.4.2550-2553.2005
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发表时间：
2005-04-01
影响因子：
3.1
通讯作者：
Hassett, DJ
中科院分区：
文献类型：
--
作者：
Lau, GW;Britigan, BE;Hassett, DJ
在小鼠和果蝇铜绿假单胞菌感染模型和中性粒细胞杀伤试验中评价了H2O2响应性反式激活因子OxyR的作用。相对于野生型细菌，oxyR突变体在急性肺炎和烧伤脓毒症的小鼠模型中存活率降低了99%或更高，并且oxyR突变体对人中性粒细胞的杀伤更敏感，并且在急性肺炎和烧伤脓毒症的动力学中延迟。
The role of the H2O2-responsive transactivator OxyR was evaluated in mouse and Drosophila models of Pseudomonas aeruginosa infection and by assays of neutrophil killing. Relative to that of wild-type bacteria, oxyR mutant viability was reduced by 99% or greater in mouse models of acute pneumonia and burn sepsis, and the oxyR mutant was more sensitive to killing by human neutrophils and was delayed in the kinetics of