Evaluation of Typhidot (IgM) for Early Diagnosis of Typhoid Fever
Evaluation of Typhidot (IgM) for Early Diagnosis of Typhoid Fever
复制标题
伤寒 (IgM) 对伤寒早期诊断的评价
DOI：
10.3329/bjmm.v3i1.2964
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Md. Abdul Khaleque
中科院分区：
文献类型：
--
作者：
Z. Begum;Md. Akram Hossain;A. Shamsuzzaman;Md. Monjurul Ahsan;A. Musa;M. Mahmud;A. A. Sumona;Salma Ahmed;N. A. Jahan;Md. Abdul Khaleque
伤寒仍然是一个主要的公共卫生问题，特别是在许多发展中国家。一种简单、可靠、经济、快速的诊断方法一直是临床医生的迫切需求。因此，我们前瞻性地评估了伤寒（IgM），血清学试验，以确定IgM抗体对伤寒沙门氏菌的敏感性和特异性。该研究于2006年6月至2007年7月在Mymensingh医学院微生物学系进行，共采集了100份临床疑似伤寒患者的样本。对每例患者进行了血培养和伤寒试验。100例临床诊断的伤寒患者中，血培养阳性14例。伤寒IgM阳性73例。培养阳性14例，其中13例（92.85%）为伤寒IgM阳性。在20例发热对照中，04例（20%）的试验也呈阳性。健康对照组伤寒IgM抗体均为阴性。以血培养为金标准的检测方法对伤寒的敏感性、特异性、阳性预测值和阴性预测值分别为92.85%、90.00%、76.47%和97.29%。Typhidot（IgM）检测是诊断伤寒的快速，易于执行和可靠的检测，适用于小型，设备较少的实验室以及设备较好的实验室。关键词：伤寒，伤寒沙门氏菌，伤寒（IgM）试验doi：10.3329/bjmm.v3i1.2964孟加拉国医学微生物学杂志2009; 03（01）：10-13
Typhoid fever still continues to be a major public health problem, particularly in many developing countries. A simple, reliable, affordable and rapid diagnostic test has been a long-felt need of the clinicians. We, therefore, prospectively evaluated the sensitivity and specificity of Typhidot (IgM), a serological test to identify IgM antibodies against Salmonella typhi . The study was carried out in the department of Microbiology, Mymensingh Medical College, Mymensingh between June, 2006 and July, 2007, on a total of 100 samples from clinically suspected patients to have typhoid fever. Blood culture as well as Typhidot test were performed for each of the cases. Out of 100 clinically diagnosed typhoid fever, 14 were blood culture positive for S. typhi and 73 were Typhidot (IgM) positive. Among 14 culture positive cases, 13 (92.85%) were Typhidot (IgM) positive. The test was also positive in 04 (20%) out of 20 febrile controls. None of the healthy controls was positive by Typhidot (IgM). The sensitivity, specificity, positive predictive value and negative predictive value of the test using blood culture as gold standard were 92.85%, 90.00%, 76.47% and 97.29% respectively for typhoid fever. Typhidot (IgM) test is rapid, easy to perform and reliable test for diagnosing typhoid fever, and useful for small, less equipped laboratories as well as for the laboratories with better facilities. Key words: Typhoid fever, Salmonella typhi , Typhidot (IgM) test doi: 10.3329/bjmm.v3i1.2964 Bangladesh J Med Microbiol 2009; 03 (01): 10-13