Evidence for striatal dopamine release during a video game
Evidence for striatal dopamine release during a video game
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DOI：
10.1038/30498
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发表时间：
1998-05-21
期刊：
影响因子：
64.8
通讯作者：
Grasby, PM
中科院分区：
文献类型：
--
作者：
Koepp, MJ;Gunn, RN;Grasby, PM
多巴胺能神经传递可能参与学习、行为强化、注意力和感觉运动整合(1，2)。放射性配基C-11标记的雷氯普利与多巴胺D-2受体的结合对内源性多巴胺水平敏感，可通过药物挑战释放(3-8)。在这里，我们使用C-11标记的拉氯普利和正电子发射断层扫描来提供证据，证明在目标定向的运动任务，即视频游戏中，内源性多巴胺在人类纹状体中释放。在视频游戏期间，拉氯普利与纹状体多巴胺受体的结合比基线结合水平显著减少，这与多巴胺与其受体的释放和结合增加一致。雷氯普利在纹状体的结合减少与任务中的操作水平呈正相关，且在腹侧纹状体的减少最大。据我们所知，这些结果第一次显示了在人类体内释放多巴胺的行为条件，并说明了正电子发射断层扫描在行为操纵期间检测体内神经递质通量的能力。
Dopaminergic neurotransmission may be involved in learning, reinforcement of behaviour, attention, and sensorimotor integration(1,2). Binding of the radioligand C-11-labelled raclopride to dopamine D-2 receptors is sensitive to levels of endogenous dopamine, which can be released by pharmacological challenge(3-8). Here we use C-11-labelled raclopride and positron emission tomography scans to provide evidence that endogenous dopamine is released in the human striatum during a goal-directed motor task, namely a video game. Binding of raclopride to dopamine receptors in the striatum was significantly reduced during the video game compared with baseline levels of binding, consistent with increased release and binding of dopamine to its receptors. The reduction in binding of raclopride in the striatum positively correlated with the performance level during the task and was greatest in the ventral striatum. These results show, to our knowledge for the first time, behavioural conditions under which dopamine is released in humans, and illustrate the ability of positron emission tomography to detect neurotransmitter fluxes in vivo during manipulations of behaviour.