Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the polycomb group gene Ring1/Ring1A
Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the polycomb group gene Ring1/Ring1A
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DOI：
10.1016/j.mod.2006.02.003
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发表时间：
2006-04-01
影响因子：
2.6
通讯作者：
Vidal, Miguel
中科院分区：
文献类型：
--
作者：
Lorente, Mar;Perez, Claudia;Vidal, Miguel
Polycomb组（PCG）蛋白参与与细胞分化相关的转录抑制状态的维持。在这里，我们显示了YYI+1-小鼠的轴向骨架的前均匀变换。我们发现，在II类PCG基因RING1/RING1A中缺乏的小鼠中，其中一些改变的外观降低了，表明这两个基因之间存在遗传相互作用。对这种相互作用的进一步支撑是RIND1缺陷小鼠中的异常前眼形成，该小鼠在化合物YY1（+1-）RING1（-1-）小鼠中得到了增强。此外，YY1与RING1和其他II类PCG蛋白（如RNF2和BMI1）形成复合物，在转染细胞中的GST下拉实验中。这些发现为脊椎动物中YY1具有PCG功能提供了证据。 （c）2006年Elsevier Ireland Ltd.保留所有权利。
Polycomb group (PcG) proteins participate in the maintenance of transcriptionally repressed state of genes relevant to cell differentiation. Here, we show anterior homeotic transformations of the axial skeleton of YYI+1- mice. We find that the penetrance of some of these alterations was reduced in mice that are deficient in the class II PcG gene Ring1/Ring1A, indicating a genetic interaction between those two genes. Further support for this interaction is an abnormal anterior eye formation in Ring1-deficient mice, which is enhanced in compound YY1(+1-)Ring1(-1-) mice. In addition, YY1 forms complexes with Ring1 and other class II PcG proteins such as Rnf2 and Bmi1 in GST pull down experiments in transfected cells. These findings provide evidence for a PcG function for YY1 in vertebrates. (c) 2006 Elsevier Ireland Ltd. All rights reserved.