The chronic gastrointestinal manifestations of Chagas disease.
The chronic gastrointestinal manifestations of Chagas disease.
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DOI：
10.1590/s1807-59322009001200013
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Evora PR
中科院分区：
文献类型：
--
作者：
Matsuda NM;Miller SM;Evora PR
查加斯病是一种由原生动物克氏锥虫引起的传染病。这种疾病主要影响神经系统、消化系统和心脏。本文回顾文献，总结恰加斯病的主要慢性胃肠道表现。查加斯病的慢性胃肠道表现主要是由锥虫引起的肠神经系统损害的结果。克氏感染最常被描述为受恰加斯病影响的解剖位置是唾液腺、食管、下食管括约肌、胃、小肠、结肠、胆囊和胆管树。查加斯病还被研究与幽门螺杆菌感染、Cajal间质细胞和胃肠道癌的发病率有关。
Chagas disease is an infectious disease caused by the protozoan Trypanosoma cruzi. The disease mainly affects the nervous system, digestive system and heart. The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease. The chronic gastrointestinal manifestations of Chagas disease are mainly a result of enteric nervous system impairment caused by T. cruzi infection. The anatomical locations most commonly described to be affected by Chagas disease are salivary glands, esophagus, lower esophageal sphincter, stomach, small intestine, colon, gallbladder and biliary tree. Chagas disease has also been studied in association with Helicobacter pylori infection, interstitial cells of Cajal and the incidence of gastrointestinal cancer.