STIMULUS-DEPENDENT NEURONAL OSCILLATIONS IN CAT VISUAL-CORTEX - INTERCOLUMNAR INTERACTION AS DETERMINED BY CROSS-CORRELATION ANALYSIS
STIMULUS-DEPENDENT NEURONAL OSCILLATIONS IN CAT VISUAL-CORTEX - INTERCOLUMNAR INTERACTION AS DETERMINED BY CROSS-CORRELATION ANALYSIS
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DOI：
10.1111/j.1460-9568.1990.tb00449.x
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发表时间：
1990-07-01
影响因子：
3.4
通讯作者：
SINGER, W
中科院分区：
文献类型：
--
作者：
ENGEL, AK;KONIG, P;SINGER, W
我们以前已经证明，猫纹状皮质中的神经元，对它们首选的刺激做出反应，在40-60赫兹的频率范围内表现出振荡反应。最近，我们获得了这样的振荡响应可以跨列同步的证据。我们现在已经对这一现象进行了广泛的分析，包括单位和场的电位响应。此外，我们还研究了导致柱间同步的刺激条件。我们用几个电极阵列记录了成年猫17区的多单位活动和局部场电位。电极间距离为0.4~12 mm。对于所有的单位势(n=200)和场势(n=174)记录，我们计算了自相关函数和互相关函数。通过将衰减正弦波(Gabor)函数与数据进行拟合来量化相关图的调制。对单位数据的交叉相关分析表明，在200例中，有90例记录的细胞建立了其振荡反应的恒定相位关系。平均而言，这种情况发生时没有相位差。如果感受野是不重叠的，我们观察到具有相似取向偏好的细胞之间主要是同步。具有重叠感受野的细胞，如果它们的取向偏好不同，也显示出高同步率。在后一组中，即使在刺激只对一个记录地点是最佳的情况下，也会发生同步。使用单眼刺激代替双眼刺激，反应的振荡调制被减弱，但交叉相关图仍显示显著的交互作用。在使用静止刺激而不是移动刺激时，也可以看到类似的效果。在174个配对记录中，有136个观察到了振荡场势响应的同步。在所研究的所有距离上，场电位响应的同步概率与细胞的取向偏好无关。然而，相互作用的强度随着空间间隔的增加而减小。对照实验表明，场电位响应的同步性不是由于体积传导引起的。结果表明，在不同的大脑皮层部位的振荡反应可以瞬时同步。同步的概率和强度取决于记录的单元格的空间分离和它们的取向偏好。此外，跨柱同步还受视觉刺激特性的影响。提示这种同步化为视皮层神经元组件的形成提供了一种机制。
We have demonstrated previously that neurons in cat striate cortex, in response to their preferred stimuli, exhibit oscillatory responses in a frequency range of 40-60 Hz. Recently, we obtained evidence that such oscillatory responses can synchronize across columns. We have now performed an extensive analysis of this phenomenon for both unit and field potential responses. In addition, we studied the stimulu conditions leading to intercolumnar synchronization. We recorded both multi-unit activity and local field potentials from area 17 of adult cats with arrays of several electrodes. Interelectrode distances ranged from 0.4 to 12 mm. For all pairs of unit (n = 200) and field potential (n = 174) recordings, we computed auto- and cross-correlation functions. The modulation of the correlograms was quantified by fitting a damped sine wave (Gabor) function to the data. Cross-correlation analysis of the unit data revealed that in 90 out of 200 cases the recorded cells established a constant phase-relationship of their oscillatory responses. This occurred, on average, with no phase difference. If the receptive fields were nonoverlapping, we observed a synchronization primarily between cells with similar orientation preferences. Cells with overlapping receptive fields also showed a high incidence of synchronization if their orientation preferences were different. In this latter group, synchronization occurred even in cases where the stimulus was optimal for only one of the recording sites. Using conditions of monocular instead of binocular stimulation the oscillatory modulation of the responses were attenuated, but the cross-correlogram still indicated a significant interaction. Similar effects were seen with the application of stationary instead of moving stimuli. A synchronization of oscillatory field potential responses was observed in 136 out of 174 paired recordings. At all distances investigated, the probability of synchronization of field potential responses was independent of the orientation preferences of the cells. However, the strength of interaction decreased with increasing spatial separation. Control experiments showed that the synchronization of field potential responses was not due to volume conduction. The results demonstrate that oscillatory responses at separate cortical sites can transiently synchronize. The probability and strength of synchronization are dependent on the spatial separation of the recorded cells and their orientation preferences. In addition, the cross-columnar synchronization is influenced by features of the visual stimulus. It is suggested that this synchronization provides a mechanism for the formation of neuronal assemblies in the visual cortex.