Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease
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DOI：
10.1016/j.neulet.2004.03.072
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发表时间：
2004-06-17
影响因子：
2.5
通讯作者：
Kang, CD
中科院分区：
文献类型：
--
作者：
Park, SW;Kim, SH;Kang, CD
多巴胺能神经元的氧化应激被认为是帕金森病（PD）神经退行性变的原因之一。研究了N-乙酰半胱氨酸（NAC）和L-2-氧代噻唑烷-4-羧酸酯（OTC）在氧化应激诱导的PD模型中是否具有预防作用。我们发现，NAC和OTC防止PARP降解过程中的自氧化多巴胺或自氧化左旋多巴诱导的PC 12细胞凋亡。在动物模型研究中，NAC和OTC显示出对MPTP诱导的酪氨酸羟化酶阳性神经元的损失的预防作用，并抑制c-jun N-末端激酶（JNK）的核转位，这表明NAC和OTC可以通过抑制JNK活化来防止MPTP诱导的细胞凋亡。因此，这些结果表明，NAC和OTC可以作为潜在的药物，以防止PD的进展。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Oxidative stress to dopaminergic neurons is believed to be one of the causes of neurodegeneration in Parkinson's disease (PD). It was investigated whether N-acetylcysteine (NAC) and L-2-oxothiazolidine-4-carboxylate (OTC) have a preventive effect in an oxidative stress-induced model of PD. We found that NAC and OTC prevent degradation of PARP during auto-oxidized dopamine- or auto-oxidized L-DOPA-induced apoptosis in PC12 cells. In an animal model study, NAC and OTC showed a preventive effect against MPTP-induced loss of tyrosine hydroxylase-positive neurons, and suppressed the nuclear translocation of c-jun N-terminal kinase (JNK), suggesting that NAC and OTC can prevent MPTP-induced apoptosis by suppressing JNK activation. Therefore, these results suggest that NAC and OTC can be used as potential agents to prevent the progression of PD. (C) 2004 Elsevier Ireland Ltd. All rights reserved.