Sarcomas in north west England: I. Histopathological peer review.
Sarcomas in north west England: I. Histopathological peer review.
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DOI：
10.1038/bjc.1991.298
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发表时间：
1991-08
影响因子：
8.8
通讯作者：
McWilliam, L J
中科院分区：
文献类型：
--
作者：
Harris, M;Hartley, A L;Blair, V;Birch, J M;Banerjee, S S;Freemont, A J;McClure, J;McWilliam, L J
在一项组织病理学同行评审、发病率和生存率的研究中，研究人员对英格兰西北部1982-84年间诊断出的468例骨、软组织和内脏肉瘤（以及某些其他肿瘤）进行了研究。本文描述了同行评议的影响。由五名病理学家组成的小组对450例最初在地区癌症登记处登记为肉瘤的病例中的413例进行了材料审查。76%的病例确诊为肉瘤，53%的病例亚型一致。最常诊断的两种亚型即恶性纤维组织细胞瘤和平滑肌肉瘤的一致性最低。个别病理学家和最终小组诊断之间的一致性程度也非常不同，但从未低于65%。结论是，在推定为肉瘤的病例中，第二意见对于发病率和病因的研究以及确保选择适当的治疗是必不可少的。
A total of 468 cases of bone, soft tissue and visceral sarcomas (and certain other tumours) diagnosed during the years 1982-84 in North West England were entered in a study of histopathological peer review, incidence and survival. This paper describes the effects of peer review. Material was reviewed by a panel of five pathologists for 413 of the 450 cases originally registered as sarcomas with the Regional Cancer Registry. The diagnosis of sarcomas was confirmed in 76% cases and and there was agreement on sub-type for 53% cases. Measures of agreement were lowest for the two sub-types most commonly diagnosed i.e. malignant fibrous histiocytoma and leiomyosarcoma. Degree of agreement between individual pathologists and final panel diagnosis was also very variable but never less than 65%. It is concluded that second opinion is essential in cases of presumed sarcomas for studies of incidence and aetiology and to ensure that appropriate treatment is selected.