Mechanisms of intimal hyperplasia learned from a murine carotid artery ligation model.
Mechanisms of intimal hyperplasia learned from a murine carotid artery ligation model.
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DOI：
10.2174/157016108783331321
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发表时间：
2008
影响因子：
4.5
通讯作者：
Le-ning Zhang;J. Parkinson;C. Haskell;Yi-xin Wang
中科院分区：
文献类型：
--
作者：
Le-ning Zhang;J. Parkinson;C. Haskell;Yi-xin Wang
小鼠颈动脉结扎(CAL)模型已被广泛应用于动脉粥样硬化和血管成形术后再狭窄等血管疾病的主要病理过程--内膜增生的研究。利用各种基因敲除或转基因小鼠和不同的药物干预，这些研究产生了重要的新发现，不仅有助于解开涉及内膜增生发病机制的基本分子机制，而且有助于确定干预这些疾病的新靶点。本文概述了小鼠CAL模型的研究结果，包括作者开展的研究，包括高脂血症、促炎因子、内皮功能障碍、蛋白酶活性和生长介质对新生内膜增生的影响。
The murine carotid artery ligation (CAL) model has been widely used in the research of intimal hyperplasia, a major pathological process in vascular diseases, such as atherosclerosis and restenosis after angioplasty. Using a variety of gene knockout or transgenic mice and different pharmacological interventions, these studies have yielded significant new findings that contribute not only to unraveling the basic molecular mechanisms involved in the pathogenesis of intimal hyperplasia, but also to the identification of novel targets for intervention of these diseases. The current review outlines the findings derived from the murine CAL model, including studies run by the authors, covering the impacts of hyperlipidemia, pro-inflammatory factors, endothelial dysfunction, protease activity and growth mediators on neointimal hyperplasia.