A viscoelastic adhesive epicardial patch for treating myocardial infarction
A viscoelastic adhesive epicardial patch for treating myocardial infarction
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一种治疗心肌梗死的粘弹性粘性心外膜补片
DOI：
10.1038/s41551-019-0380-9
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发表时间：
2019-08-01
影响因子：
28.1
通讯作者：
Gao, Huajian
中科院分区：
文献类型：
--
作者：
Lin, Xiao;Liu, Yue;Gao, Huajian
通过增加受损左心室组织的机械完整性来治疗心肌梗死的脱细胞心外膜补片表现出广泛分散的治疗功效。在这里，我们介绍了一种粘弹性粘合剂补丁，由离子交联的透明水凝胶，可容纳心肌的周期性变形，并优于大多数现有的脱细胞心外膜补丁逆转左心室重构和恢复心脏功能后，急性和亚急性心肌梗死大鼠。贴片的上级性能源于其相对较低的动态模量，通过左心室重塑的有限元模拟在所谓的“凝胶点”处设计，以平衡材料的流体和固体性质。
Acellular epicardial patches that treat myocardial infarction by increasing the mechanical integrity of damaged left ventricular tissues exhibit widely scattered therapeutic efficacy. Here, we introduce a viscoelastic adhesive patch, made of an ionically crosslinked transparent hydrogel, that accommodates the cyclic deformation of the myocardium and outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and restoring heart function after both acute and subacute myocardial infarction in rats. The superior performance of the patch results from its relatively low dynamic modulus, designed at the so-called 'gel point' via finite-element simulations of left ventricular remodelling so as to balance the fluid and solid properties of the material.