Anabolism - Low mechanical signals strengthen long bones
Anabolism - Low mechanical signals strengthen long bones
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DOI：
10.1038/35088122
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发表时间：
2001-08-09
期刊：
影响因子：
64.8
通讯作者：
McLeod, K
中科院分区：
文献类型：
--
作者：
Rubin, C;Turner, AS;McLeod, K
尽管骨骼的承重适应性已被人们认识了一个多世纪，但负责强化骨骼的具体机械部件尚未确定。在这里，我们发现，在一年内每天对成年羊的后肢进行 20 分钟的极低强度、高频振动的机械刺激后，股骨近端海绵（小梁）骨的密度与对照组相比显着增加（增加了 34.2%）。由于这种治疗产生的应变水平比损伤骨组织的应变水平低三个数量级，因此这种合成代谢、非侵入性刺激可能具有治疗骨质疏松症等骨骼疾病的潜力。
Although the skeleton's adaptability to load-bearing has been recognized for over a century, the specific mechanical components responsible for strengthening it have not been identified. Here we show that after mechanically stimulating the hindlimbs of adult sheep on a daily basis for a year with 20-minute bursts of very-low-magnitude, high-frequency vibration, the density of the spongy (trabecular) bone in the proximal femur is significantly increased (by 34.2%) compared to controls. As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis.