A SURVEY COMPARING THE CHEMICAL-COMPOSITION OF DICOFOL FORMULATIONS SOLD IN THE UK BEFORE AND AFTER THE INTRODUCTION OF THE EC PROHIBITION DIRECTIVE-79/117/EEC
A SURVEY COMPARING THE CHEMICAL-COMPOSITION OF DICOFOL FORMULATIONS SOLD IN THE UK BEFORE AND AFTER THE INTRODUCTION OF THE EC PROHIBITION DIRECTIVE-79/117/EEC
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DOI：
10.1002/ps.2780420408
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发表时间：
1994-12-01
期刊：
影响因子：
--
通讯作者：
WILKINS, JPG
中科院分区：
文献类型：
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作者：
GILLESPIE, MJ;LYTHGO, CM;WILKINS, JPG
对五家公司销售的38种配方的分析表明，这些产品的有效成分含量范围在92%至112%之间，三氯杀螨醇在92%至112%之间，而雷公藤则在107%至142%之间。三氯杀螨醇的制造方法产生与滴滴涕有关的杂质。欧洲通过了一项禁止指令，要求与滴滴涕有关的杂质在三氯杀螨醇含量中所占比例低于1g kg-1。在禁止指令之前生产的配方中含有这些杂质，配方中的三氯杀螨醇最高可达575g kg-1。在该指令之后生产的配方中含有这些杂质，配方中的三氯杀螨醇最高可达7g kg-1。在较新的配方中检测到的杂质较少；仅存在o，o‘-DDE、o，m’-DDE、o，p‘-DDE、m，p’-DDE、p，p‘-DDE、o，p’-氯-DDT和p，p‘-氯-DDT。在13个样品中，有8个样品的配方中三氯杀螨醇的含量低于0.1g kg-1，其中含有与滴滴涕有关的杂质。在指令后生产的配方中发现的主要杂质(按浓度计算)是与DDT无关的制造副产品，如邻苯二氯苯。
Analysis of 38 formulations marketed by five companies indicated that the active ingredient contents of these products are within the range of 92 to 112%, for dicofol, and 107 to 142%, for tetradifon, of that declared. Manufacturing procedures for dicofol produce impurities related to DDT. The adoption of a prohibition directive in Europe requires that DDT-related impurities represent less than 1 g kg-1 of the dicofol content. Formulations manufactured before the prohibition directive contained these impurities at up to 575 g kg-1 of the dicofol in the formulation. Formulations manufactured after the directive contained these impurities at up to 7 g kg-1 of the dicofol in the formulation. Fewer impurities were detected in the more recent formulations; only o,o'-DDE, o,m'-DDE, o,p'-DDE, m,p'-DDE, p,p'-DDE, o,p'-chloro-DDT and p,p'-chloro-DDT were present. Eight of the 13 samples contained DDT-related impurities at less than 0.1 g kg-1 of the dicofol in the formulation. The major impurities found in formulations manufactured after the directive (in concentration terms) are non DDT-related manufacturing byproducts such as o,p'-dichlorobenzil.