Mouse complement: the effect of sex hormones and castration on two of the late-acting components.
Mouse complement: the effect of sex hormones and castration on two of the late-acting components.
复制标题
DOI：
10.1084/jem.125.4.657
复制
发表时间：
1967-04-01
期刊：
影响因子：
--
通讯作者：
Rapp HJ
中科院分区：
文献类型：
--
作者：
Churchill WH Jr;Weintraub RM;Borsos T;Rapp HJ
雄性小鼠血清中迟效补体成分的滴度比雌性小鼠血清的滴度高8-10倍。使用开发的测定方法来测量两种迟效成分的血清含量，我们已经表明，这种差异是由于雄激素和雌激素对这两种迟效补体成分的影响。这两种组分已被初步鉴定为C '5和C' 6。雄激素和雌激素对C '6的影响大于C' 5。尚未排除的可能性是，还有其他的晚作用补体成分受到雄激素和雌激素的影响。在C '5和C' 6缺陷的小鼠中，同种移植物排斥反应的过程没有改变。
The titer of late-acting complement components in sera from male mice is 8–10 times higher than the titer of sera from female mice. Using assays developed to measure the serum content of two of the late-acting components, we have shown that this difference is due to the effect of androgen and estrogen on these two late-acting complement components. These two components have been tentatively identified as C'5 and C'6. Androgen and estrogen have greater effect on C'6 than on C'5. The possibility has not been excluded that still other of the late-acting complement components are affected by androgens and estrogens. The course of homograft rejection was unchanged in mice deficient in C'5 and C'6.