Parent-child conflict and the comorbidity among childhood externalizing disorders
Parent-child conflict and the comorbidity among childhood externalizing disorders
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DOI：
10.1001/archpsyc.60.5.505
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发表时间：
2003-05-01
影响因子：
--
通讯作者：
Iacono, W
中科院分区：
文献类型：
--
作者：
Burt, SA;Krueger, RF;Iacono, W
背景：先前的研究表明，儿童外化障碍之间存在大量的共病，特别是注意力缺陷/多动障碍(ADHD)、对立违抗障碍(ODD)和品行障碍(CD)。此外，亲子冲突预测了这些障碍中的每一个。我们的目标是确定亲子冲突是否与ADHD、CD和ODD之间的共病有关，并通过遗传信息设计明确地检查这种关联的病因。方法：我们比较了以下两种生物统计学模型的适用性：两因素共同路径模型，它考察了遗传和环境对冲突和三种疾病之间的协变的贡献；乔列斯基模型，它单独检查冲突和每种疾病之间的关系。样本包括来自明尼苏达州双胞胎家庭研究的808对11岁的同性双胞胎，这是一项基于人群的明尼苏达州双胞胎及其家庭样本。主要结果测量包括ADHD、CD和ODD的症状计数，这是从对双胞胎及其母亲进行的结构化访谈中获得的。亲子冲突通过母亲和双胞胎的父母环境问卷进行评估。结果：双因素模型对数据有较好的拟合。这些结果表明，冲突通过遗传和环境因素解释了疾病之间的协变的33%。结论：亲子冲突似乎是一种常见的易感性，增加了儿童多发性疾病的风险。此外，这种联系是通过共同的遗传和环境因素来调节的。这些发现支持这样一种观点，即这些障碍之间的共病部分反映了家庭环境中的核心精神病理过程，这些过程可能将独立的精神障碍联系在一起。
Background: Previous research has suggested that substantial comorbidity exists among childhood externalizing disorders, specifically attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). Moreover, parent-child conflict predicts each of these disorders. Our goals were to determine whether parent-child conflict was associated with the comorbidity among ADHD, CD, and ODD, and to explicitly examine the etiology of this association via a genetically informative design.Methods: We compared the fit of the following 2 biometric models: the 2-factor common-pathway model, which examined genetic and environmental contributions to the relationship between conflict and the covariation among the 3 disorders, and the Cholesky model, which examined the relationship between conflict and each disorder individually. The sample consisted of 808 same-sex 11-year-old twin pairs from the Minnesota Twin Family Study, a population-based sample of Minnesota twins and their families. Main outcome measures included symptom counts for ADHD, CD, and ODD, obtained from structured interviews administered to twins and their mothers. Parent-child conflict was assessed via mother and twin reports of the Parental Environment Questionnaire.Results: The 2-factor model provided a better fit to the data. These results indicated that conflict accounted for 33% of the covariation among the disorders, via genetic and environmental factors.Conclusions: Parent-child conflict appears to act as a common vulnerability that increases risk for multiple childhood disorders. Furthermore, this association is mediated via common genetic and environmental factors. These findings support the idea that the comorbidity among these disorders partially reflects core psychopathological processes in the family environment that link putatively separate psychiatric disorders.