Auditory evoked potentials in aged gerbils: Responses elicited by noises separated by a silent gap
Auditory evoked potentials in aged gerbils: Responses elicited by noises separated by a silent gap
复制标题
DOI：
10.1016/s0378-5955(96)90016-7
复制
发表时间：
1996-12-01
期刊：
影响因子：
2.8
通讯作者：
Holley, BL
中科院分区：
文献类型：
--
作者：
Boettcher, FA;Mills, JH;Holley, BL
复合动作电位（CAP）和听觉脑干反应（ABR;波ii和iv）记录在年轻（4-8个月）和老年（33-37个月）沙鼠使用的范式类似于在一些心理物理学研究中使用的间隙检测（一对相同的低通噪声分离的无声间隙）。根据绝对振幅和“振幅比”（对第二噪声的响应振幅除以对第一噪声的响应振幅）分析响应振幅。根据绝对潜伏期以及“潜伏期偏移”（对第二噪声的反应的潜伏期减去对第一噪声的反应的潜伏期）分析反应潜伏期。反应幅度小得多，在老年受试者的第一和第二刺激对。CAP和ABR的振幅比随年龄变化很小。对于一对中的第一个刺激，两组之间的绝对潜伏期相似，但当差距较短时，老年受试者的潜伏期到第四波的时间要长得多。因此，与年轻组相比，老年组的波iv的潜伏期偏移要长得多，但两组之间的ABR的CAP或波ii的潜伏期偏移相似。结果提示，老年沙鼠听觉脑干的时间信息编码可能发生了变化，而这种变化并不是听觉外周的异常时间加工的直接结果。
The compound action potential (CAP) and the auditory brainstem response (ABR; waves ii and iv) were recorded in young (4-8 month) and aged (33-37 month) gerbils using a paradigm similar to that used in some psychophysical studies of gap detection (a pair of identical low-pass noises separated by a silent gap). Response amplitudes were analyzed in terms of absolute amplitudes and the 'amplitude ratio' (the amplitude of the response to the second noise of a pair divided by that to the first). Response latencies were analyzed in terms of the absolute latencies as well as the 'latency shift' (the latency of the response to the second noise minus that to the first). Response amplitudes were much smaller in the aged subjects for both the first and second stimuli of a pair. There were minimal changes in amplitude ratios across age for both the CAP and ABR. Absolute latencies were similar between groups for the first stimulus of a pair, but latencies to wave iv were much longer for the aged subjects when the gap was short. Thus, the latency shift for the aged group was much longer for wave iv in the aged compared to the young group, but were similar between groups for the CAP or wave ii of the ABR. The results suggest that there may be changes in coding of temporal information in the auditory brainstem of aged gerbils which are not a direct result of abnormal temporal processing in the auditory periphery.