Simultaneous Regeneration of Bone and Nerves Through Materials and Architectural Design: Are We There Yet?
Simultaneous Regeneration of Bone and Nerves Through Materials and Architectural Design: Are We There Yet?
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DOI：
10.1002/adfm.202003542
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发表时间：
2020-09
影响因子：
19
通讯作者：
Q. Wan;W. Qin;Minjuan Shen;Yu-Xuan Ma;Bei Li;Shi‐Yu Liu;F. Tay;K. Jiao;L. Niu
中科院分区：
文献类型：
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作者：
Q. Wan;W. Qin;Minjuan Shen;Yu-Xuan Ma;Bei Li;Shi‐Yu Liu;F. Tay;K. Jiao;L. Niu
骨和神经之间的双向沟通对于修复大型骨缺损以及骨骼内周围神经的修复至关重要。然而，骨骼和神经的同时再生是一个在以前的文献中长期被忽视的问题。骨和神经的不协调甚至相互矛盾的要求或再生环境使得多个组织的同时再生具有挑战性。本综述首先介绍了骨和神经之间的自然串扰，强调了骨和神经同时再生的基本原理。这些问题将为灵感材料设计概念的发展铺平道路，这些概念利用骨传导、骨诱导、神经传导、神经诱导和神经吸引的原理。潜在的战略，基于选择适当的支架，无细胞生物因素和建筑设计将被处理。
Bilateral communication between bone and nerves is crucial for optimal repair of large bone defects as well as repair of peripheral nerves within the skeleton. However, simultaneous regeneration of bone and nerves is an issue that has long been overlooked in prior literature. Incongruous or even contradictory requirements or regeneration environments for bone and nerves make simultaneous regeneration of multiple tissues challenging. The present review commences with introducing natural crosstalk between bone and nerves, highlighting the rationale for simultaneous regeneration of bone and nerves. These issues will pave the way for the development of inspirational materials design concepts that capitalize on the principles of osteoconduction, osteoinduction, neuroconduction, neuroinduction, and neuroattraction. Potential strategies based on selection of appropriate scaffolds, acellular biological factors and architectural design will be addressed.