Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango, Mexico
Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango, Mexico
复制标题
DOI：
10.1186/1471-2334-7-75
复制
发表时间：
2007-07-13
影响因子：
3.7
通讯作者：
Martinez-Garcia, Sergio Arturo
中科院分区：
文献类型：
--
作者：
Alvarado-Esquivel, Cosme;Mercado-Suarez, Miguel Francisco;Martinez-Garcia, Sergio Arturo
背景：献血者感染弓形虫（T. gondii）可能存在在受血者中传播的风险。关于墨西哥献血者弓形虫感染流行病学的信息很少。因此，我们试图确定墨西哥杜兰戈市健康献血者群体中弓形虫感染的患病率以及相关的社会人口学和行为特征。方法：2006 年 8 月至 9 月期间，对墨西哥杜兰戈市两个公共血库的 432 名献血者进行了弓形虫感染检查。使用酶联免疫测定法检测弓形虫 IgG 和 IgM 抗体（Diagnostic Automation Inc.，卡拉巴萨斯，加利福尼亚州，美国）。还获得了每个参与者的社会人口统计和行为特征。结果：432 名献血者中有 32 名 (7.4%) 具有 IgG 抗 T 蛋白。弓形虫抗体。其中 8 名 (1.9%) 也有 IgM 抗 T。弓形虫抗体。使用逻辑回归的多变量分析表明，弓形虫感染与家里有猫有关（调整后 OR = 3.81；95% CI：1.45-10.01）。 45-60岁年龄组的弓形虫感染频率显着高于25-34岁年龄组（p = 0.02）。未受过教育的献血者的感染频率 (15.8%) 明显高于受过 13-19 年教育的献血者 (4.5%) (p = 0.04)。献血者的其他特征，包括男性、食用未煮熟的肉类或输血，均未显示与感染相关。结论：墨西哥杜兰戈市健康献血者中弓形虫感染率低于墨西哥南部和中部献血者报告的感染率，是全球献血者中报告的感染率最低的地区之一。我们的献血者感染弓形虫很可能是通过与猫接触而感染的。感染率随着年龄的增长而增加，随着教育水平的增加而降低。
Background: Toxoplasma gondii (T. gondii) infection in blood donors could represent a risk for transmission in blood recipients. There is scarce information about the epidemiology of T. gondii infection in blood donors in Mexico. Therefore, we sought to determine the prevalence of T. gondii infection and associated sociodemographic and behavioral characteristics in a population of healthy blood donors of Durango City, Mexico.Methods: Four hundred and thirty two blood donors in two public blood banks of Durango City, Mexico were examined for T. gondii infection between August to September 2006. Blood donors were tested for anti-T. gondii IgG and IgM antibodies by using enzyme-linked immunoassays (Diagnostic Automation Inc., Calabasas, CA, USA). Socio-demographic and behavioral characteristics from each participant were also obtained.Results: Thirty two (7.4%) of 432 blood donors had IgG anti-T. gondii antibodies. Eight (1.9%) of them had also IgM anti-T. gondii antibodies. Multivariate analysis using logic regression showed that T. gondii infection was associated with the presence of cats at home (adjusted OR = 3.81; 95% CI: 1.45-10.01). The age group of 45-60 years showed a significantly higher frequency of T. gondii infection than the group of 25-34 years (p = 0.02). Blood donors without education had a significantly higher frequency of infection (15.8%) than those with 13-19 years of education (4.5%) (p = 0.04). Other characteristics of blood donors including male gender, consumption of undercooked meat or blood transfusion did not show an association with infection.Conclusion: The prevalence of T. gondii infection in healthy blood donors of Durango City, Mexico is lower than those reported in blood donors of south and central Mexico, and is one of the lowest reported in blood donors worldwide. T. gondii infection in our blood donors was most likely acquired by contact with cats. Prevalence of infection increased with age and decreased with educational level.