Cellular Immunotherapy Targeting Cancer Stem Cells: Preclinical Evidence and Clinical Perspective.
Cellular Immunotherapy Targeting Cancer Stem Cells: Preclinical Evidence and Clinical Perspective.
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DOI：
10.3390/cells10030543
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发表时间：
2021-03-04
期刊：
影响因子：
6
通讯作者：
Leuci V
中科院分区：
文献类型：
--
作者：
Donini C;Rotolo R;Proment A;Aglietta M;Sangiolo D;Leuci V
术语“癌症干细胞”（CSC）通常是指具有干细胞特征的肿瘤细胞的子集，其潜在地涉及化学抗性和疾病复发。CSC可能存在特殊的免疫原性特征，影响其在肿瘤微环境中的稳态。CSC对免疫系统识别和靶向的敏感性是一个相关的问题和研究事项，特别是考虑到多种新兴的免疫治疗策略。连续性细胞免疫疗法，特别是那些包含嵌合抗原受体（CAR）的遗传重定向的策略，在几种肿瘤环境中具有相关的前景，并且在理论上可能提供选择性消除CSC亚群的机会。最初的专门临床前研究支持细胞免疫疗法对CSC的潜在靶向作用，可能来自临床研究的间接证据，新的研究正在进行中。在这里，我们回顾了与CSCs的假定免疫原性相关的主要问题，重点关注并强调了T和非T抗肿瘤淋巴细胞的细胞免疫治疗方法的现有证据和机会。
The term “cancer stem cells” (CSCs) commonly refers to a subset of tumor cells endowed with stemness features, potentially involved in chemo-resistance and disease relapses. CSCs may present peculiar immunogenic features influencing their homeostasis within the tumor microenvironment. The susceptibility of CSCs to recognition and targeting by the immune system is a relevant issue and matter of investigation, especially considering the multiple emerging immunotherapy strategies. Adoptive cellular immunotherapies, especially those strategies encompassing the genetic redirection with chimeric antigen receptors (CAR), hold relevant promise in several tumor settings and might in theory provide opportunities for selective elimination of CSC subsets. Initial dedicated preclinical studies are supporting the potential targeting of CSCs by cellular immunotherapies, indirect evidence from clinical studies may be derived and new studies are ongoing. Here we review the main issues related to the putative immunogenicity of CSCs, focusing on and highlighting the existing evidence and opportunities for cellular immunotherapy approaches with T and non-T antitumor lymphocytes.
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DOI：
10.1126/science.aac9935
发表时间：
2016-04-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Casey SC;Tong L;Li Y;Do R;Walz S;Fitzgerald KN;Gouw AM;Baylot V;Gütgemann I;Eilers M;Felsher DW
通讯作者：
Felsher DW
影响因子：
32.4
作者：
Agudo J;Park ES;Rose SA;Alibo E;Sweeney R;Dhainaut M;Kobayashi KS;Sachidanandam R;Baccarini A;Merad M;Brown BD
通讯作者：
Brown BD
影响因子：
4
作者：
Chen HC;Joalland N;Bridgeman JS;Alchami FS;Jarry U;Khan MWA;Piggott L;Shanneik Y;Li J;Herold MJ;Herrmann T;Price DA;Gallimore AM;Clarkson RW;Scotet E;Moser B;Eberl M
通讯作者：
Eberl M
影响因子：
20.3
作者：
Baker, J;Verneris, MR;Negrin, RS
通讯作者：
Negrin, RS
影响因子：
13
作者：
Cappuzzello, Elisa;Sommaggio, Roberta;Rosato, Antonio
通讯作者：
Rosato, Antonio