Electron paramagnetic resonance and dynamic nuclear polarization of char suspensions: surface science and oximetry
Electron paramagnetic resonance and dynamic nuclear polarization of char suspensions: surface science and oximetry
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DOI：
10.1088/0031-9155/43/7/012
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发表时间：
1998-07-01
影响因子：
3.5
通讯作者：
Belford, RL
中科院分区：
文献类型：
--
作者：
Clarkson, RB;Odintsov, BM;Belford, RL
在我们的实验室中，通过高度受控的热解技术，从各种起始原料合成了炭。这些炭表现出电子顺磁共振（EPR）线的形状与当地的氧气浓度变化在一个可重复的和稳定的方式，它们可以被校准和用于血氧测定。生物稳定性和低毒性使炭成为体内测量的良好传感器。在煤焦表面的水质子的标量和偶极相互作用可以被用来产生动态核极化（DNP）的H-1核自旋人口与电子塞曼泵。低频EPR，DNP和DNP增强MRI都显示出与碳焦一起使用时作为血氧测定方法的前景。
Carbon chars have been synthesized in our laboratory from a variety of starting materials, by means of a highly controlled pyrolysis technique. These chars exhibit electron paramagnetic resonance (EPR) line shapes which change with the local oxygen concentration in a reproducible and stable fashion; they can be calibrated and used for oximetry. Biological stability and low toxicity make chars good sensors for in vivo measurements. Scalar and dipolar interactions of water protons at the surfaces of chars may be utilized to produce dynamic nuclear polarization (DNP) of the H-1 nuclear spin population in conjunction with electron Zeeman pumping. Low-frequency EPR, DNP and DNP-enhanced MRI all show promise as oximetry methods when used with carbon chars.