Stem cell stimulation of endogenous myocyte regeneration.
Stem cell stimulation of endogenous myocyte regeneration.
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干细胞刺激内源性心肌再生。
DOI：
10.1042/cs20120641
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Canty JM Jr
中科院分区：
文献类型：
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作者：
Weil BR;Canty JM Jr
基于细胞的治疗已经成为一种有前途的方法，以打击心肌细胞损失和心脏重塑的特点，左心室功能障碍的进展，心力衰竭。在过去十年中进行的几项临床试验表明，各种自体骨髓和外周血来源的干细胞和祖细胞群可以安全地给予缺血性心脏病患者，并产生心脏功能的适度改善。同时，在临床前水平上已经取得了快速进展，以确定新的治疗性细胞群，描绘细胞介导的心脏修复的机制，并优化基于细胞的方法用于临床应用。以下综述总结了在过去十年中在这一快速发展的领域取得的进展，并探讨了我们目前对成功心脏再生机制的理解如何指导这一领域的未来研究。特别强调的是放在讨论的一般假设，细胞治疗的好处主要是由于刺激内源性心脏修复过程，最近才被确定在成年哺乳动物的心脏，而不是直接分化的外源性细胞。在这一领域的持续科学研究将指导基于细胞的心肌再生方法的优化，最终目标是临床实施和大幅提高我们恢复缺血性心脏病患者心脏功能的能力。
Cell-based therapy has emerged as a promising approach to combat the myocyte loss and cardiac remodeling that characterize the progression of left ventricular dysfunction to heart failure. Several clinical trials conducted during the past decade have shown that a variety of autologous bone marrow- and peripheral blood-derived stem and progenitor cell populations can be safely administered to patients with ischemic heart disease and yield modest improvements in cardiac function. Concurrently, rapid progress has been made at the preclinical level to identify novel therapeutic cell populations, delineate the mechanisms underlying cell-mediated cardiac repair, and optimize cell-based approaches for clinical use. The following review summarizes the progress that has been made in this rapidly evolving field over the past decade and examines how our current understanding of the mechanisms involved in successful cardiac regeneration should direct future investigation in this area. Particular emphasis is placed on discussion of the general hypothesis that the benefits of cell therapy primarily result from stimulation of endogenous cardiac repair processes that have only recently been identified in the adult mammalian heart, rather than direct differentiation of exogenous cells. Continued scientific investigation in this area will guide the optimization of cell-based approaches for myocardial regeneration, with the ultimate goal of clinical implementation and substantial improvement in our ability to restore cardiac function in ischemic heart disease patients.