Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.
Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.
复制标题
红藻氨酸受体基因家族的完全破坏导致小鼠皮质纹状体功能障碍。
DOI：
10.1016/j.celrep.2017.01.073
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发表时间：
2017
期刊：
影响因子：
8.8
通讯作者：
Contractor,Anis
中科院分区：
文献类型：
--
作者：
Xu,Jian;Marshall,JohnJ;Fernandes,HermanB;Nomura,Toshihiro;Copits,BryanA;Procissi,Daniele;Mori,Susumu;Wang,Lei;Zhu,Yongling;Swanson,GeoffreyT;Contractor,Anis
Kainate receptors are members of the glutamate receptor family that regulate synaptic function in the brain. They modulate synaptic transmission and the excitability of neurons; however, their contributions to neural circuits that underlie behavior are unclear. To understand the net impact of kainate receptor signaling, we generated knockout mice in which all five kainate receptor subunits were ablated (5ko). These mice displayed compulsive and perseverative behaviors, including over-grooming, as well as motor problems, indicative of alterations in striatal circuits. There were deficits in corticostriatal input to spiny projection neurons (SPNs) in the dorsal striatum and correlated reductions in spine density. The behavioral alterations were not present in mice only lacking the primary receptor subunit expressed in adult striatum (GluK2 KO), suggesting that signaling through multiple receptor types is required for proper striatal function. This demonstrates that alterations in striatal function dominate the behavioral phenotype in mice without kainate receptors.
