Coexpression of calretinin and parvalbumin in Ruffini-like endings in the rat incisor periodontal ligament
Coexpression of calretinin and parvalbumin in Ruffini-like endings in the rat incisor periodontal ligament
复制标题
大鼠切牙牙周膜 Ruffini 样末端中钙视网膜素和小清蛋白的共表达
DOI：
10.1016/s0006-8993(97)00826-3
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发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
T. Sugimoto
中科院分区：
文献类型：
--
作者：
H. Ichikawa;D. Jacobowitz;T. Sugimoto
用免疫组织化学方法检测了大鼠口面部组织中钙视网膜蛋白（CR）和小清蛋白（irs）的共表达。神经纤维共表达这些钙结合蛋白（CaBPs），观察到在舌牙周膜的切牙，而不是其他组织。在牙周膜邻近牙槽骨的部分，这些神经纤维离开神经束并形成类似于神经纤维的终末，它们反复分叉，并以1至4个细枝终止。免疫电镜方法表明，这些结束是相同的Ruffini样的结束。4%的下牙槽神经逆行标记的三叉神经元同时表达CR-和parvalbumin-irs。目前的观察表明，这些CaBP的共表达可能是三叉神经节中低阈值机械感受器的特异性标记。
The coexpression of calretinin- (CR) and parvalbumin-immunoreactivities (irs) was examined in oro-facial tissues of the rat. Nerve fibers coexpressing these calcium-binding proteins (CaBPs) were observed in the lingual periodontal ligament of incisors but not other tissues. In the part of periodontal ligament adjacent to the alveolar bone, such nerve fibers left nerve bundles and formed bush-like endings, i.e., they ramified repeatedly and terminated with one to four twigs. An immunoelectron microscopic method indicated that these endings were identical to Ruffini-like endings. 4% of trigeminal neurons retrogradely labeled from the inferior alveolar nerve coexpressed CR- and parvalbumin-irs. The present observations suggest that the coexpression of these CaBPs may be a specific marker for low-threshold mechanoreceptors in the trigeminal ganglion.