Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis
Efficacy of Recombinant Human BMP2 and PDGF-BB in Orofacial Bone Regeneration: A Systematic Review and Meta-analysis
复制标题
重组人 BMP2 和 PDGF-BB 在口面部骨再生中的功效：系统评价和荟萃分析
DOI：
10.1038/s41598-019-44368-z
复制
发表时间：
2019-05-30
影响因子：
4.6
通讯作者：
Ye, Ling
中科院分区：
文献类型：
--
作者：
Li, Feifei;Yu, Fanyuan;Ye, Ling
随着组织工程疗法的快速发展，人们对应用重组人生长因子（rhGF）再生人类口面部骨越来越感兴趣。然而，尽管有报道称它们在动物实验中能够促进口面部骨再生，但它们在人类临床治疗中的益处仍不清楚。此外，特定rhGF的适当浓度或适应症仍然不明确。因此，有必要从不同的临床试验中收集数据，以更准确地评估其效果。在此，我们回顾了重点关注 rhGF 在口面部骨再生中的应用的随机临床试验 (RCT)。提取、汇总纳入研究的数据，然后根据预先制定的方案进行定量分析。我们的结果表明，目前所有浓度的 rhBMP-2 对于促进拔牙槽愈合、上颌窦增大或牙槽裂重建都没有产生足够的效果。然而，0.3mg/ml rhPDGF-BB 可以促进拔牙槽的愈合，但效果未达到统计学显着水平。总之，我们推荐0.3mg/ml rhPDGF-BB 的浓度仅用于拔牙槽的愈合。
With the rapid development of tissue engineering therapies, there is a growing interest in the application of recombinant human growth factors (rhGFs) to regenerate human orofacial bones. However, despite reports of their ability to promote orofacial bone regeneration in animal experiments, their benefits in human clinical treatments remain unclear. Furthermore, the appropriate concentrations or indications of a specific rhGF remain ambiguous. Therefore it is essential to collect data from diverse clinical trials to evaluate their effects more precisely. Here we reviewed randomized clinical trials (RCT) that focused on the utilization of rhGFs in orofacial bone regeneration. Data from included studies were extracted, pooled and then quantitatively analyzed according to a pre-established protocol. Our results indicate that all current concentrations of rhBMP-2 produces insufficient effect on promoting either tooth extraction socket healing, sinus augmentation or reconstruction of alveolar clefts. However, 0.3 mg/ml rhPDGF-BB promotes the healing of tooth extraction sockets, though the effect does not reach a level of statistical significance. Summarily, we recommend concentrations of 0.3 mg/ml rhPDGF-BB only for the healing of tooth extraction sockets.