The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors
The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors
复制标题
缺氧诱导因子2在实体瘤化疗/放疗耐药中的新作用
DOI：
10.1016/j.ctrv.2015.05.004
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发表时间：
2015
影响因子：
11.8
通讯作者：
Xu Binghe
中科院分区：
文献类型：
--
作者：
Zhao Jiuda;Du Feng;Luo Yang;Shen Guoshuang;Zheng Fangchao;Xu Binghe
低氧条件是一个常见的特征，对实体瘤的放疗和化疗的疗效产生负面影响。缺氧诱导因子（HIF-1、2、3）主要在细胞或生物体水平调节对缺氧的适应。HIF-2是HIF转录因子的三个已知α亚基之一。已有研究表明HIF-1与化疗失败有关。近年来越来越多的证据表明，HIF-2也有助于实体瘤的化疗/放射抵抗。尽管HIF-1α和HIF-2α具有相似的结构，但在低氧条件下，它们在实体瘤中的作用高度不同，甚至相反。最近的研究还表明，HIF-2α通过与HIF-1α不同的机制在化疗/辐射抗性中发挥作用，至少部分是这样。本文综述了HIF-2在实体瘤化疗/放疗耐药中的作用及其导致这一病理过程的新机制。
The hypoxic condition is a common feature that negatively impacts the efficacy of radio- and chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate the adaptation to hypoxia at the cellular or organismal level. HIF-2 is one of the three known alpha subunits of HIF transcription factors. Previous studies have shown that HIF-1 is associated with chemotherapy failure. Accumulating evidence in recent years suggests that HIF-2 also contributes to chemo/radioresistance in solid tumors. Despite sharing similar structures, HIF-1α and HIF-2α had highly divergent and even opposing roles in solid tumors under hypoxic conditions. Recent studies have also implied that HIF-2α had a role in chemo/radioresistance through different mechanisms, at least partly, compared to HIF-1α. The present paper summarizes the function of HIF-2 in chemo/radioresistance in solid tumors as well as some of its novel mechanisms that contributed to this pathological process.