In vitro activity of clinafloxacin in comparison with other quinolones against Stenotrophomonas maltophilia clinical isolates in the presence and absence of reserpine
In vitro activity of clinafloxacin in comparison with other quinolones against Stenotrophomonas maltophilia clinical isolates in the presence and absence of reserpine
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DOI：
10.1016/s0732-8893(01)00335-2
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发表时间：
2002-02-01
影响因子：
2.9
通讯作者：
Vila, J
中科院分区：
文献类型：
--
作者：
Ribera, A;Jurado, A;Vila, J
对33株嗜麦芽窄食单胞菌临床分离株进行克林沙星敏感性试验，并与环丙沙星、左氧氟沙星、诺氟沙星、萘啶酸、司帕沙星、曲伐沙星进行比较。MIC 50和MIC 90如下：环丙沙星4和64 μ g/mL，克林沙星0.5和4 μ g/mL;左氧氟沙星2和32 μ g/mL;阿托沙星I和8 μ g/mL;萘啶酸8和128 μ g/mL;去甲万古霉素64和256 μ g/mL，司帕沙星I和16 μ g/mL;曲伐沙星I和8 μ g/mL。克林伐他汀是最活跃的喹诺酮类药物，只有15.1%的菌株显示出耐药性。当在25 μ g/ml利血平存在下测定MIC时，曲伐沙星和阿托沙星的MIC 90没有变化，而克林沙星、左氧氟沙星、司帕沙星和萘啶酸的MIC 90降低2倍，环丙沙星和诺氟沙星的MIC 90分别降低4倍和8倍。当在利血平存在下进行MIC时，未观察到克林沙星耐药菌株。因此，克林霉素对这33株沙门氏菌显示出较好的“体外”活性。嗜麦芽窄食症(C)2002年爱思唯尔科技有限公司All rights reserved.
A total of 33 Stenotrophomonas maltophilia clinical isolates were tested for their susceptibility to clinafloxacin in comparison with ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin, sparfloxacin and trovafloxacin. The MIC50 and MIC90 were as follows: ciprofloxacin 4 and 64 mug/mL clinafoxacin 0.5 and 4 mug/mL; levofloxacin 2 and 32 mug/mL; moxifloxacin I and 8 mug/mL; nalidixic acid 8 and 128 mug/mL; norfloxucin 64 and 256 mug/mL, sparfloxacin I and 16 mug/mL; and trovafloxacin I and 8 mug/mL. Clinafloxacin was the most active quinolone, with only a 15.1% of strains showing resistance. When the MICs were determined in the presence of 25 mug/ml of reserpine, the MIC90 of trovafloxacin and moxifloxacin did not change, whereas decreased 2-fold for clinafloxacin, levofloxacin, sparfloxacin and nalidixic acid, and 4- and 8-fold for ciprofloxacin and norfloxacin respectively. No clinafloxacin-resistant strains were observed when the MIC was performed in the presence of reserpine. Therefore, clinafloxacin shows the better "in vitro" activity against these 33 strains of S. maltophilia. (C) 2002 Elsevier Science Inc. All rights reserved.