Mesothelin and kidney function-Analysis of relationship and implications for mesothelioma screening
Mesothelin and kidney function-Analysis of relationship and implications for mesothelioma screening
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DOI：
10.1016/j.lungcan.2011.01.011
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发表时间：
2011-09-01
期刊：
影响因子：
5.3
通讯作者：
Creaney, Jenette
中科院分区：
文献类型：
--
作者：
Boudville, Neil;Paul, Rohan;Creaney, Jenette
目的：恶性间皮瘤（MM）预后不良，在许多国家仍然是一个主要的公共卫生问题。结果可能会改善与早期检测，这证明筛选的风险石棉暴露人群。可溶性间皮素是MM的潜在生物标志物，但已观察到其在肾功能降低的患者中升高。定义间皮素浓度和肾功能之间的关系，将允许更准确的解释本assay.Materials和方法：一个横断面研究，包括144例慢性肾脏疾病（CKD）进行了查尔斯·盖尔登爵士医院和皇家珀斯医院在西澳大利亚州。仅招募CKD II-V期患者，排除有肾移植、透析或恶性肿瘤病史的患者。结果：入选CKD Ⅱ、Ⅲ、Ⅳ、Ⅴ期患者分别为33、49、31、31例。血清间皮素随血清肌酐升高而显著升高（p < 0.0001），随CKD病情加重而显著升高（p < 0.0001）。检测到尿间皮素与肌酸酐比率和血清间皮素浓度之间的显著相关性（p = 0.002）。尿间皮素肌酐比值在四个CKD分期groups.Conclusion：血清间皮素浓度升高，在个人肾功能不全。因此，在解释本试验时应考虑肾功能。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Purpose: Malignant mesothelioma (MM) carries a poor prognosis and remains a major public health issue in many countries. Outcomes may be improved with earlier detection and this justifies screening the at-risk asbestos-exposed population. Soluble mesothelin is a potential biomarker for MM, but it has been observed to be elevated in patients with reduced kidney function. Defining the relationship between mesothelin concentrations and kidney function will allow more accurate interpretation of this assay.Materials and methods: A cross-sectional study consisting of 144 patients with chronic kidney disease (CKD) was conducted at Sir Charles Gairdner Hospital and Royal Perth Hospital in Western Australia. Only patients with CKD stages II-V were recruited while those with a history of renal transplant, dialysis, or malignancy were excluded. Serum and urine mesothelin and creatinine concentrations were determined.Results: There were 33, 49, 31 and 31 patients in CKD stages II, III, IV and V, respectively recruited. Serum mesothelin increased significantly with increasing serum creatinine (p < 0.0001), and worsening stage of CKD (p < 0.0001). A significant correlation between urine mesothelin to creatinine ratio and serum mesothelin concentration was detected (p = 0.002). No significant difference was found in urine mesothelin to creatinine ratios across the four CKD stage groups.Conclusion: Serum mesothelin concentration is elevated in individuals with renal impairment. Renal function should therefore be taken into account during interpretation of this assay. (C) 2011 Elsevier Ireland Ltd. All rights reserved.