Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia
Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia
复制标题
DOI：
10.1006/nimg.2002.1157
复制
发表时间：
2002-09-01
期刊：
影响因子：
5.7
通讯作者：
Alfano, B
中科院分区：
文献类型：
--
作者：
Quarantelli, M;Larobina, M;Alfano, B
根据Talairach Atlas的研究，一种对主要结构（额叶，顶，枕骨和颞叶；小脑半球；小脑半球）进行自动定义的分段常规脑MRI研究的方法。该方法适用于来自25名正常受试者（NV），14例缺陷精神分裂症（DS）的MRI研究，14例患有非缺乏精神分裂症（NDS）的患者，以评估其灰质和CSF区域大容量。两名患者群体在疾病发作时的平均年龄没有差异，疾病的持续时间，精神病症状的严重程度或混乱； DS比NDS具有更严重的航行和更差的社交功能。出于验证目的，在10项研究中，在原始MR图像上手动概述了大脑结构，从而获得了参考度量。手动和自动措施分开了一个月，以测量两种方法的再生能力。每项研究的自动化方法需要少于1分钟/操作员，而手动评估则需要超过30分钟。两种技术之间的平均每个结构的绝对差为4.8 mL。两种方法之间的总体可重复性没有显着差异。在精神分裂症患者中，发现GM显着降低和CSF的增加。通用汽车损失仅限于额叶和颞叶。与NV相比，NDS的双侧侧心在双侧的双侧明显更大，而在NDS的右侧与DS相比。 NDS中更大的结构性脑异常的发现增加了缺陷精神分裂症并不代表更严重的精神分裂症连续体的证据。 （C）2002 Elsevier Science（美国）。
A method for postprocessing of segmented routine brain MRI studies providing automated definition of major structures (frontal, parietal, occipital, and temporal lobes; cerebellar hemispheres; and lateral ventricles) according to the Talairach atlas is presented. The method was applied to MRI studies from 25 normal subjects (NV), 14 patients with deficit schizophrenia (DS), and 14 with nondeficit schizophrenia (NDS), to evaluate their gray matter and CSF regional volumes. The two patient groups did not differ in mean age at illness onset, duration of illness, severity of psychotic symptoms, or disorganization; DS had more severe avolition and worse social functioning than NDS. For validation purposes, brain structures were manually outlined on original MR images in 10 studies, thus obtaining reference measures. Manual and automated measures were repeated I month apart to measure reproducibilities of both methods. The automated method required less than 1 min/operator per study vs more than 30 min for manual assessment. Mean absolute difference per structure between the two techniques was 4.8 ml. Overall reproducibility did not significantly differ between the two methods. In subjects with schizophrenia, a significant decrease in GM and increase in CSF were found. GM loss was confined to frontal and temporal lobes. Lateral ventricles were significantly larger bilaterally in NDS compared to NV and only on the right in NDS compared to DS. The finding of greater structural brain abnormalities in NDS adds to the evidence that deficit schizophrenia does not represent just the more severe end of the schizophrenia continuum. (C) 2002 Elsevier Science (USA).