Linkage between immune response potential to DNA and X chromosome
Linkage between immune response potential to DNA and X chromosome
复制标题
DNA 和 X 染色体免疫反应潜力之间的联系
作者：
E. Mozes;S. Fuchs
对核酸免疫应答调节的兴趣主要源于系统性红斑狼疮患者血清中抗核酸抗体的自发发生1 -4。遗传因素似乎在这种疾病中起作用，这与某些人类移植抗原有关。在一些小鼠品系中观察到针对不同形式的核酸的抗体的自发产生，并且被认为与自身免疫性疾病相关1 - 4，6 -8。有趣的是，发现不同小鼠品系在主动免疫时对核酸的应答潜力是否与抗体的自发发生和/或自身免疫样疾病有关。
INTEREST in the regulation of the immune response to nucleic acids stems largely from the spontaneous occurrence of anti-nucleic acid antibodies in the sera of patients with systemic lupus erythematosus1–4. Genetic factors seem to play a role in this disease, which is associated with certain human transplantation antigens5. Spontaneous production of antibodies to different forms of nucleic acids has been observed in some mouse strains, and is suggested to be correlated with autoimmune diseases1–4,6–8. It is of interest to find out whether the response potential of different mouse strains to nucleic acids, on active immunisation, is related to the spontaneous occurrence of antibodies and/or to autoimmune-like diseases.