The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.
The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.
复制标题
某些秀丽隐杆线虫突变体的多外阴表型是由两条功能冗余途径的缺陷引起的。
DOI：
10.1093/genetics/123.1.109
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发表时间：
1989
期刊：
影响因子：
3.3
通讯作者：
Horvitz,HR
中科院分区：
文献类型：
--
作者：
Ferguson,EL;Horvitz,HR
我们以前确定秀丽隐杆线虫突变体中的某些六外阴前体细胞采用的命运通常由其他外阴前体细胞表达。这些突变体定义的基因似乎在响应诱导外阴发育的细胞间信号中起作用。其中一个突变体CB 1322的多叶藻（Muv）表型是由两个非连锁突变lin-8（n111）II和lin-9（n112）III之间的相互作用引起的。在本文中，我们确定了18个新的突变，这是8个基因的等位基因，与lin-8（n111）或lin-9（n112）相互作用，产生Muv表型。这20个突变中没有一个单独引起任何外阴细胞谱系缺陷。“沉默Muv”突变分为两类;携带每一类突变的雌雄同体是Muv，而携带同一类的两个突变的雌雄同体具有野生型外阴表型。我们的研究结果表明，这些突变体的Muv表型的结果从两个功能冗余途径的缺陷，从而表明冗余可以发生在基因途径的水平，以及在基因家族的水平。
We previously identified Caenorhabditis elegans mutants in which certain of the six vulval precursor cells adopt fates normally expressed by other vulval precursor cells. These mutants define genes that appear to function in the response to an intercellular signal that induces vulval development. The multivulva (Muv) phenotype of one such mutant, CB1322, results from an interaction between two unlinked mutations, lin-8(n111) II and lin-9(n112) III. In this paper, we identify 18 new mutations, which are alleles of eight genes, that interact with either lin-8(n111) or lin-9(n112) to generate a Muv phenotype. None of these 20 mutations alone causes any vulval cell lineage defects. The "silent Muv" mutations fall into two classes; hermaphrodites carrying a mutation of each class are Muv, while hermaphrodites carrying two mutations of the same class have a wild-type vulval phenotype. Our results indicate that the Muv phenotype of these mutants results from defects in two functionally-redundant pathways, thereby demonstrating that redundancy can occur at the level of gene pathways as well as at the level of gene families.