Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia.
Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia.
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DOI：
10.1111/jnc.14218
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发表时间：
2018-03
影响因子：
4.7
通讯作者：
Rosenberg GA
中科院分区：
文献类型：
--
作者：
Rosenberg GA
血管性认知障碍和痴呆（VCID）是一个主要的公共卫生问题，因为血管疾病的发病率在老龄化人口和血管疾病的影响阿尔茨海默氏病。VCID是一组异质性疾病，目前尚无有效的治疗方法。生物标志物可用于选择更同质的群体。小血管疾病是VCID最常见的形式，并且是治疗试验的最佳形式，因为存在具有特征性病理变化的进行性过程。皮质下缺血性血管病的宾斯旺格型（SIVD-BD）有一个特征集，可用于识别患者和后续治疗。SIVD-BD患者具有可用作生物标志物的临床、神经心理学、CSF和影像学特征。没有一个特征是诊断性的，但多模式方法定义了SIVD-BD谱系障碍。最重要的特征是大的白色病变伴轴突损伤，MRI和CSF显示血脑屏障破坏，以及执行功能障碍的神经心理学证据。我们已经使用这些功能来创建Binswanger疾病量表和SIVD-BD的概率，使用机器学习算法。本综述中讨论的患者来自已发表的研究。生物标志物有助于在疾病进程进展太远而无法治疗之前进行早期诊断，但也可以指示对治疗的反应。完善生物标志物的使用将使痴呆症治疗进入精准医学时代。血管性认知障碍和痴呆（VCID）是一个主要的公共卫生问题，因为血管疾病的发病率在老龄化人口和血管疾病的影响阿尔茨海默氏病。皮质下缺血性血管病的宾斯旺格型（SIVD-BD）有一个特征集，可用于识别患者和后续治疗。我们使用临床特征来创建Binswanger疾病量表和SIVD-BD的概率，使用机器学习算法。完善生物标志物的使用将使痴呆症治疗进入精准医学时代。示意图显示了慢性血管疾病中涉及血脑屏障开放的基质金属蛋白酶机制。
Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer’s disease. VCID is a heterogeneous group of diseases for which there are no proven treatments. Biomarkers can be used to select more homogeneous populations. Small vessel disease is the most prevalent form of VCID and is the optimal form for treatment trials because there is a progressive course with characteristic pathological changes. Subcortical ischemic vascular disease of the Binswanger type (SIVD-BD) has a characteristic set of features that can be used both to identify patients and to follow treatment. SIVD-BD patients have clinical, neuropsychological, CSF and imaging features that can be used as biomarkers. No one feature is diagnostic but a multimodal approach defines the SIVD-BD spectrum disorder. The most important features are large white matter lesions with axonal damage, blood-brain barrier disruption as shown by MRI and CSF, and neuropsychological evidence of executive dysfunction. We have used these features to create a Binswanger Disease Scale and a probability of SIVD-BD, using a machine-learning algorithms. The patients discussed in this review are derived from published studies. Biomarkers aid in early diagnosis before the disease process have progressed too far for treatment, but also can indicate response to treatment. Refining the use of biomarkers will allow dementia treatment to enter the era of precision medicine. Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer’s disease. Subcortical ischemic vascular disease of the Binswanger type (SIVD-BD) has a characteristic set of features that can be used both to identify patients and to follow treatment. We have used clinical features to create a Binswanger Disease Scale and a probability of SIVD-BD, using a machine-learning algorithms. Refining the use of biomarkers will allow dementia treatment to enter the era of precision medicine. The schematic shows the matrix metalloprotinase mechanism involved in blood-brain barrier opening in chronic vascular disease.
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影响因子：
8.3
作者：
Candelario-Jalil E;Thompson J;Taheri S;Grossetete M;Adair JC;Edmonds E;Prestopnik J;Wills J;Rosenberg GA
通讯作者：
Rosenberg GA
影响因子：
3.6
作者：
Hawkins KE;DeMars KM;Yang C;Rosenberg GA;Candelario-Jalil E
通讯作者：
Candelario-Jalil E
DOI：
10.1191/1352458502ms800oa
发表时间：
2002-05-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Liuzzi, GM;Trojano, M;Riccio, P
通讯作者：
Riccio, P
影响因子：
8.3
作者：
de Groot, Marius;Verhaaren, Benjamin F. J.;Vernooij, Meike W.
通讯作者：
Vernooij, Meike W.
影响因子：
--
作者：
HACHINSKI, VC;POTTER, P;MERSKEY, H
通讯作者：
MERSKEY, H