Age effects on properties of motor unit action potentials: ADEMG analysis
Age effects on properties of motor unit action potentials: ADEMG analysis
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年龄对运动单位动作电位特性的影响：ADEMG 分析
DOI：
10.1002/ana.410240206
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发表时间：
1988
影响因子：
11.2
通讯作者：
L. Dorfman
中科院分区：
文献类型：
--
作者：
Januarye E. Howard;K. McGill;L. Dorfman
我们测量了10名年轻人（20-40岁）、10名中年人（40-60岁）和10名老年人（60-80岁）的肱二头肌、肱三头肌和胫骨前肌的13206个运动单位动作电位（muap）的构型和发射特性，使用了12月自动合成肌电图（EMG）干扰模式（ADEMG）的方法。使用标准同心针电极在最大自主收缩阈值、10%和30%的稳定等距收缩时进行记录。在超阈值力作用下，在每个记录位点平均鉴定出5.9个同时活跃的muap。在低阈值和高阈值muap中，平均振幅、持续时间和旋转次数均随年龄线性增加（p < 0.01），表明持续的渐进式去神经支配和代偿性神经再生过程。当按比例测量力时，平均MUAP射击率随年龄增加而增加（p = 0.01），但绝对测量时则没有。在一个由12对年龄匹配的性别组成的亚组中，男性的平均MUAP振幅、上升率和匝数更大（p < 0.05），这可能反映了更大的肌纤维直径。这些发现放大了以往最低阈值单个muap的传统分析结果；建立ADEMG规范成人数据基础；进一步验证快速、自动肌电12月合成的临床适用性。
We have measured the configurational and firing properties of 13,206 motor unit action potentials (MUAPs) from the brachial biceps, brachial triceps, and anterior tibial muscles in 10 young (20–40 years), 10 middle‐aged (40–60 years), and 10 elderly (60–80 years) normal individuals, using an automatic method for Decemberomposition of the electromyo‐graphic (EMG) interference pattern (ADEMG). Recordings were made during stable isometric contractions at threshold, 10%, and 30% of maximum voluntary contraction using standard concentric needle electrodes. At supra‐threshold forces, an average of 5.9 simultaneously active MUAPs were identified at each recording site. Mean amplitudes, durations, and numbers of turns all increased linearly with age in both low‐threshold and high‐threshold MUAPs (p < 0.01), suggesting an ongoing process of progressive denervation and compensatory reinnervation. Mean MUAP firing rates Decemberreased with age (p = 0.01) when force was measured proportionately, but not when measured absolutely. In a subgroup of 12 age‐matched gender pairs, men had larger mean MUAP amplitudes, rise rates, and numbers of turns (p < 0.05), probably reflecting larger muscle fiber diameters. These findings amplify previous observations from traditional analysis of lowest‐threshold single MUAPs; establish a base of normative adult data for ADEMG; and further validate the clinical applicability of rapid, automatic EMG Decemberomposition.