The Role of Vitamin D in the Aging Adult.
The Role of Vitamin D in the Aging Adult.
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DOI：
10.12974/2309-6128.2014.02.02.1
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Penckofer S
中科院分区：
文献类型：
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作者：
Meehan M;Penckofer S
预计从2012年到2060年，65岁及以上的人口数量将增加一倍以上。维生素D在预防和治疗与衰老有关的疾病中的作用尚未得到充分研究。传统上，维生素D的作用集中在维持老年人的骨骼健康。随着维生素D受体在神经、心血管和内分泌系统中的发现，维生素D的作用及其对这些系统的影响已成为研究的重要领域。由于皮肤合成和饮食摄入维生素D减少，老年人维生素D水平较低。流行病学证据表明，低水平的维生素D和与衰老相关的疾病之间存在关联，如认知能力下降、抑郁症、骨质疏松症、心血管疾病、高血压、2型糖尿病和癌症。确定补充维生素D对预防和治疗这些疾病的益处的临床试验正在进行中。本文强调了目前关于维生素D在与衰老相关的疾病中可能发挥作用的证据，并提出了设计良好的随机试验的必要性，以检查其对老年人健康结果的益处。
The number of individuals aged 65 and older is expected to more than double from 2012 to 2060. The role of vitamin D in the prevention and treatment of diseases associated with aging has not been well studied. Traditionally, the role of vitamin D focused on the maintenance of skeletal health in the older adult. With the discovery of vitamin D receptors in the nervous, cardiovascular and endocrine systems, the role of vitamin D and its impact on these systems has become an important area of research. Older adults are at risk for lower levels of vitamin D as a result of decreased cutaneous synthesis and dietary intake of vitamin D. Epidemiologic evidence indicates an association between low levels of vitamin D and diseases associated with aging such as cognitive decline, depression, osteoporosis, cardiovascular disease, hypertension, type 2 diabetes, and cancer. Clinical trials to determine the benefit of vitamin D supplementation in preventing and treating such diseases are in progress. This paper highlights current evidence regarding the role that vitamin D may play in diseases associated with aging and addresses the need for well-designed randomized trials to examine its benefit on health outcomes in the older adult.